University of Utah Department of Biomedical Engineering, 36 South Wasatch Drive, Salt Lake City, UT 84112, USA; University of Utah Interdepartmental Neuroscience Program, 20 South 2030 East, Salt Lake City, UT 84102, USA.
University of Utah Interdepartmental Neuroscience Program, 20 South 2030 East, Salt Lake City, UT 84102, USA; University of Utah Department of Radiology and Imaging Sciences, 1A71 School of Medicine, Salt Lake City, UT 84132, USA.
Psychiatry Res Neuroimaging. 2019 Sep 30;291:52-62. doi: 10.1016/j.pscychresns.2019.08.001. Epub 2019 Aug 2.
Functional MRI connectivity has identified neurophysiology relevant to cognition and personality, motivating a search for relationships between brain architecture and emotional health and well-being. Two approaches were used to asses functional connectivity correlates of emotional health and well-being. The first approach used principal component analysis to evaluate resting-state functional magnetic resonance imaging data from the Human Connectome Project 1200 Subjects Data Release. Pairwise functional connectivity measurements were obtained from a 5 mm resolution parcellation of brain gray matter. Principal components were calculated for each individual and for group mean connectivity data and compared to obtain an estimate of typicality of functional connectivity for each component in each subject. Typicality scores were compared to reported emotional health metrics using a general linear model. The second approach calculated functional connectivity between each pair of networks from a 17-resting-state network cortical parcellation. Typicality of connectivity showed significant correlation across the population to emotional metrics corresponding to attitudes of anger and aggression in 3 of 10 principal components. Additionally, functional connectivity between the default and attentional networks was positively correlated with scores of attitudes of anger and aggression. These findings are consistent with a mechanism of impaired effortful control and decreased response inhibition of impulsivity.
功能磁共振成像连接已确定与认知和个性相关的神经生理学，这激发了人们对大脑结构与情绪健康和幸福感之间关系的研究。采用两种方法来评估情绪健康和幸福感的功能连接相关性。第一种方法使用主成分分析来评估人类连接组计划 1200 个主题数据发布的静息状态功能磁共振成像数据。从大脑灰质的 5 毫米分辨率分割中获得了成对的功能连接测量值。为每个个体和组平均连接数据计算了主成分，并进行比较，以获得每个个体中每个成分的功能连接典型性的估计。使用一般线性模型将典型性得分与报告的情绪健康指标进行比较。第二种方法从 17 个静息状态网络皮质分割中计算了每个网络对之间的功能连接。典型性的连接在整个人群中与对应于愤怒和攻击态度的情绪指标显著相关，在 10 个主成分中的 3 个中。此外，默认网络和注意力网络之间的功能连接与愤怒和攻击态度的得分呈正相关。这些发现与一种机制一致，即努力控制受损和冲动的反应抑制能力下降。
