通过含银、锶和硅的微弧磷酸钙涂层对钛表面进行改性。
Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating.
作者信息
Sedelnikova Mariya B, Komarova Ekaterina G, Sharkeev Yurii P, Ugodchikova Anna V, Tolkacheva Tatiana V, Rau Julietta V, Buyko Evgeny E, Ivanov Vladimir V, Sheikin Vladimir V
机构信息
Institute of Strength Physics and Materials Science of SB RAS, Academicheskii Prospect 2/4, Tomsk, 634055, Russia.
National Research Tomsk Polytechnic University, Lenina Prospect 30, Tomsk, 634050, Russia.
出版信息
Bioact Mater. 2019 Aug 2;4:224-235. doi: 10.1016/j.bioactmat.2019.07.001. eCollection 2019 Dec.
The current research is devoted to the study of the modification of the titanium implants by the micro-arc oxidation with bioactive calcium phosphate coatings containing Ag or Sr and Si elements. The coatings' microstructure, phase composition, morphology, physicochemical and biological properties were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). Ag-containing and Sr-Si-incorporated coatings were formed in alkaline and acid electrolytes, respectively. The formation of the coatings occurred at different ranges of the applied voltages, which led to the significant difference in the coatings properties. The trace elements Ag, Sr and Si participated intensively in the plasma-chemical reactions of the micro-arc coatings formation. Ag-containing coatings demonstrated strong antibacterial effect against AТСС 6538-P. MTT test with 3T3-L1 fibroblasts showed no cytotoxicity appearance on Sr-Si-incorporated coatings.
当前的研究致力于通过微弧氧化对钛植入物进行改性，制备含有银、锶和硅元素的生物活性磷酸钙涂层。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、能量色散X射线光谱（EDX）和X射线衍射（XRD）对涂层的微观结构、相组成、形态、物理化学和生物学性能进行了研究。含银涂层和含锶-硅涂层分别在碱性和酸性电解液中形成。涂层在不同的外加电压范围内形成，这导致了涂层性能的显著差异。微量元素银、锶和硅在微弧涂层形成的等离子体化学反应中积极参与。含银涂层对ATCC 6538-P表现出强烈的抗菌作用。对3T3-L1成纤维细胞进行的MTT试验表明，含锶-硅涂层没有细胞毒性表现。
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