Holgado M A, Anguiano-Domínguez A, Martín-Banderas L
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, España.
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, España.
Arch Soc Esp Oftalmol (Engl Ed). 2020 Jan;95(1):24-33. doi: 10.1016/j.oftal.2019.07.009. Epub 2019 Aug 13.
The ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical technology, attempts have been made to use various solutions in order to increase bioavailability in the most common pharmaceutical forms, it has not been entirely satisfactory. In this context, contact lenses are presented as drug delivery systems that largely remedy these two major problems and offer other additional advantages. Therefore, the use of contact lenses as drug carrying systems has been increasingly investigated in recent years, as they can increase the bioavailability of these drugs, leading to an increase in therapeutic efficacy and compliance. The main techniques used to achieve this goal are included in this review, including immersion in drug solutions, use of vitamin E barriers, molecular printing, colloidal systems, etc. The most interesting results, depending on the different eye pathologies, are presented. Although the use of contact lenses as a vehicle for the release of active ingredients is a relatively novel strategy, there are already many studies and trials that support it. In any case, further research needs to be carried out to finally reach an effective, safe, and stable product that can be marketed.
使用传统药物剂型（包括眼药水或眼药膏）进行眼部给药，生物利用度较低，且每天需要多次给药，随之而来的是治疗依从性差的风险。尽管通过药物技术手段，人们尝试使用各种溶液来提高最常见药物剂型的生物利用度，但效果并不完全令人满意。在这种背景下，隐形眼镜作为药物递送系统，在很大程度上弥补了这两个主要问题，并具有其他额外优势。因此，近年来，将隐形眼镜用作载药系统的研究越来越多，因为它们可以提高这些药物的生物利用度，从而提高治疗效果和依从性。本综述涵盖了用于实现这一目标的主要技术，包括浸泡在药物溶液中、使用维生素E屏障、分子印迹、胶体系统等。文中展示了根据不同眼部疾病所取得的最有趣的研究成果。尽管将隐形眼镜用作活性成分释放载体是一种相对新颖的策略，但已有许多研究和试验支持这一做法。无论如何，仍需进一步开展研究，以最终获得一种有效、安全且稳定的可上市产品。
