Esmaeili Saeid, Akbari Aghdam Hossein, Motififard Mehdi, Saber-Samandari Saeed, Montazeran Amir Hussein, Bigonah Mohammad, Sheikhbahaei Erfan, Khandan Amirsalar
New Technologies Research Center, Amirkabir University of Technology, Tehran, 15875-4413, Iran.
Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Eur J Orthop Surg Traumatol. 2020 Jan;30(1):123-131. doi: 10.1007/s00590-019-02530-3. Epub 2019 Aug 16.
One of the most common fractures in the skeleton happens in the femur. One of the important reasons for this fracture is because it is the longest bone in the body and osteoporosis affect this part a lot. The geometric complexity and anisotropy properties of this bone have received a lot of attention in the orthopedic field.
In this research, a femur designed using 3D printing machine using the middle part of the hip made of polylactic acid-hydroxyapatite (PLA-HA) nanocomposite containing 0, 5, 10, 15, and 25 wt% of ceramic nanoparticle. Three different types of loadings, including centralized loading, full-scale, and partially loaded, were applied to the designed femur bone. The finite element analysis was used to analyze biomechanical components.
The results of the analysis showed that it is possible to use the porous scaffold model for replacement in the femur having proper strength and mechanical stability. Stress-strain analysis on femoral implant with biometric HA and PLA after modeling was performed using the finite element method under static conditions in Abaqus software.
Three scaffold structures, i.e., mono-, hybrid, and zonal structures, that can be fabricated using current bioprinting techniques are also discussed with respect to scaffold design.
人体骨骼中最常见的骨折之一发生在股骨。这种骨折的一个重要原因是它是人体最长的骨头，且骨质疏松对该部位影响很大。这块骨头的几何复杂性和各向异性特性在骨科领域受到了很多关注。
在本研究中，使用3D打印机设计了一种股骨，其使用由含0、5、10、15和25重量%陶瓷纳米颗粒的聚乳酸 - 羟基磷灰石（PLA - HA）纳米复合材料制成的髋部中间部分。对设计的股骨施加三种不同类型的载荷，包括集中载荷、全尺寸载荷和部分载荷。采用有限元分析来分析生物力学成分。
分析结果表明，使用具有适当强度和机械稳定性的多孔支架模型来替代股骨是可行的。在Abaqus软件的静态条件下，使用有限元方法对建模后的含生物活性HA和PLA的股骨植入物进行了应力 - 应变分析。
还针对支架设计讨论了可以使用当前生物打印技术制造的三种支架结构，即单一结构、混合结构和分区结构。
