小鼠T淋巴细胞抗原识别中的贴壁细胞功能。IV. 人白细胞热原增强小鼠T细胞抗原识别作用
Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen.
作者信息
Rosenwasser L J, Dinarello C A, Rosenthal A S
出版信息
J Exp Med. 1979 Sep 19;150(3):709-14. doi: 10.1084/jem.150.3.709.
Abstract
A macrophage-dependent, antigen-specific murine T-cell proliferation assay was utilized to examine the role of soluble products of murine and human adherent cells in the activation of T lymphocytes. Highly purified human leukocytic pyrogen, and supernates from both murine and human mononuclear phagocytes-macrophages stimulated the immune T-cell proliferative response to the multideterminant antigens dinitrophenyl-ovalbumin and keyhole limpet hemocyanin. The implications of these studies and the relationship of leukocytic pyrogen to human lymphocyte-activating factor are discussed.
摘要
采用一种依赖巨噬细胞的、抗原特异性的小鼠T细胞增殖试验，来检测小鼠和人贴壁细胞的可溶性产物在T淋巴细胞激活中的作用。高纯度的人白细胞热原以及小鼠和人单核吞噬细胞（巨噬细胞）的上清液，均可刺激免疫T细胞对多决定簇抗原二硝基苯基卵清蛋白和钥孔戚血蓝蛋白的增殖反应。本文讨论了这些研究的意义以及白细胞热原与人类淋巴细胞激活因子的关系。
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