Wan Yusuf Wan Nazirah, Wan Mohammad Wan Mohd Zahiruddin, Gan Siew Hua, Mustafa Mahiran, Abd Aziz Che Badariah, Sulaiman Siti Amrah
Pharmacology Department, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
Biostatistics Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
J Tradit Complement Med. 2018 Sep 28;9(4):249-256. doi: 10.1016/j.jtcme.2018.05.003. eCollection 2019 Oct.
This is the first study to report on the effects of honey in asymptomatic HIV positive subjects in ameliorating CD4 count, viral load (VL) and quality of life (QOL). It is a randomized, controlled, open labelled study, comparing the effects of Tualang honey (TH) administration for six months at three different doses: 20 g (THL), 40 g (THI) or 60 g (THH) daily compared with control (no administered treatment, THC). Only asymptomatic HIV positive subjects (n=95) having CD4 count 250-600 cell/ml, not on antiretrovirals were enrolled. Blood, (together with QOL questionnaires administration) were investigated at baseline, three and six months (CD4 cell count) while VL was determined only at baseline and six months. Significant reductions in CD4 counts in THL and THC groups (p= 0.003 for both) were seen with no significant reductions in the CD4 counts in THI and THH groups (p=0.447 and 0.053 respectively). There was improvement in VL in THC and THI (130% and 32% respectively) and reductions in THL and THH (26% and 8% respectively). Within and between group analyses for VL indicated significant differences between THL and THH compared to THC. In addition, significant improvement in QOL of groups which received TH was noted. TH has the potential to improve the QOL (physical and psychological) and CD4 counts. There was a trend of lower VL in asymptomatic HIV subjects following TH administration thus supporting the possible role of TH in boosting the immune system by improving CD4 counts, causing VL reductions in HIV positive subjects.
这是第一项报告蜂蜜对无症状HIV阳性受试者改善CD4细胞计数、病毒载量（VL）和生活质量（QOL）影响的研究。这是一项随机、对照、开放标签研究，比较了三种不同剂量（每日20克（THL）、40克（THI）或60克（THH））的土琅蜂蜜（TH）连续六个月给药的效果，与对照组（未给予治疗，THC）进行对比。仅纳入了CD4细胞计数为250 - 600个细胞/毫升、未接受抗逆转录病毒治疗的无症状HIV阳性受试者（n = 95）。在基线、三个月和六个月时对血液（同时进行QOL问卷调查）进行研究以检测CD4细胞计数，而VL仅在基线和六个月时测定。THL组和THC组的CD4细胞计数显著降低（两者p = 0.003），而THI组和THH组的CD4细胞计数无显著降低（分别为p = 0.447和0.053）。THC组和THI组的VL有所改善（分别为130%和32%），THL组和THH组的VL有所降低（分别为26%和8%）。VL的组内和组间分析表明，与THC相比，THL组和THH组之间存在显著差异。此外，接受TH的组在QOL方面有显著改善。TH有改善QOL（身体和心理方面）以及CD4细胞计数的潜力。给予TH后，无症状HIV受试者的VL有降低趋势，从而支持了TH可能通过改善CD4细胞计数来增强免疫系统，导致HIV阳性受试者VL降低的作用。
