Zhang Qing-Wei, Zhai Chang-Bin, Ma Dong-Li
Beijing Institute of Ophthalmology; Beijing Tongren Eye Center; Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Int J Ophthalmol. 2019 Aug 18;12(8):1311-1316. doi: 10.18240/ijo.2019.08.12. eCollection 2019.
To explore whether the same corneal curvature parameters and anterior chamber depth measured by Pentacam and VX120 have a good consistency and can replace each other.
This study enrolled 140 eyes of 70 patients ranging in age from 19 to 53y. All eyes underwent a comprehensive ophthalmologic examination including an anterior segment analysis with the VX120 system (Visionix-Luneau Technologies, Chartres, France) and Pentacam (Oculus Optikgerate GmbH) respectively. The comparison on corneal curvature parameters was done between Pentacam and VX120 using clustered signed rank test; the interclass correlation coefficients (ICC) with 95% confidence intervals (CI) was calculated for each parameter between Pentacam and VX120; the Bland-Altman plot of each parameter was supplemented.
The anterior corneal curvature measured by VX120 was Ks: 44.00±1.78 D, KsAt: 89.45±22.18, Kf: 42.84±1.58 D, KfAt: 93.91±79.34; which measured by Pentacam was Ks: 43.80±1.82 D, KsAt: 91.17±21.40, Kf: 42.61±1.64 D, KfAt: 91.16±78.69. There was statistical difference between Pentacam and VX120 for anterior corneal curvature parameter (<0.001). The posterior corneal curvature measured by VX120 was Ks: -6.42±1.23 D, KsAt: 91.00±23.45, Kf: -5.85±1.24 D, KfAt: 95.93±79.11; which measured by Pentacam was Ks: -6.44±0.32 D, KsAt: 92.24±11.75, Kf: -6.01±1.05 D, KfAt: 74.43±80.64. There was statistical difference between Pentacam and VX120 for posterior corneal curvature parameters (<0.001). Anterior chamber depth (ACD) measured by Pentacam and VX120 was statistically different. Pentacam and VX120 achieved high consistency only on corneal anterior surface, including Ks and Kf. The ICCs were 0.96 (95%CI: 0.95, 0.97) and 0.95 (95%CI: 0.94, 0.97) respectively. For other corneal surface curvature parameters, all ICCs of between Pentacam and VX120 were below 0.87. Bland-Altman plots indicated of low consistency of corneal surface curvature parameters measured by Pentacam and VX120.
The corneal curvature parameters and anterior chamber depth measured by Pentacam and VX120 were statistically different. Data measured by Pentacam and VX120 is not suggested to replace each other, mixing data measured by Pentacam and VX120 together is not suggested either.
探讨Pentacam和VX120测量的相同角膜曲率参数及前房深度是否具有良好的一致性以及能否相互替代。
本研究纳入70例年龄在19至53岁之间患者的140只眼。所有眼睛均接受了全面的眼科检查，分别使用VX120系统（法国沙特尔Visionix-Luneau Technologies公司）和Pentacam（德国Oculus Optikgerate GmbH公司）进行眼前节分析。采用聚类符号秩检验对Pentacam和VX120的角膜曲率参数进行比较；计算Pentacam和VX120各参数的组内相关系数（ICC）及其95%置信区间（CI）；补充各参数的Bland-Altman图。
VX120测量的前角膜曲率为Ks：44.00±1.78 D，KsAt：89.45±22.18，Kf：42.84±1.58 D，KfAt：93.91±79.34；Pentacam测量的为Ks：43.80±1.82 D，KsAt：91.17±21.40，Kf：42.61±1.64 D，KfAt：91.16±78.69。Pentacam和VX120在前角膜曲率参数方面存在统计学差异（<0.001）。VX120测量的后角膜曲率为Ks：-6.42±1.23 D，KsAt：91.00±23.45，Kf：-5.85±1.24 D，KfAt：95.93±79.11；Pentacam测量的为Ks：-6.44±0.32 D，KsAt：92.24±11.75，Kf：-6.01±1.05 D，KfAt：74.43±80.64。Pentacam和VX120在后角膜曲率参数方面存在统计学差异（<0.001）。Pentacam和VX120测量的前房深度（ACD）存在统计学差异。Pentacam和VX120仅在角膜前表面（包括Ks和Kf）具有较高的一致性，ICC分别为0.96（95%CI：0.95，0.97）和0.95（95%CI：0.94，0.97）。对于其他角膜表面曲率参数，Pentacam和VX120之间的所有ICC均低于0.87。Bland-Altman图表明Pentacam和VX120测量的角膜表面曲率参数一致性较低。
Pentacam和VX120测量的角膜曲率参数及前房深度存在统计学差异。不建议Pentacam和VX120的数据相互替代，也不建议将Pentacam和VX120测量的数据混合使用。
