Supiyaphun Chantaka, Rattanasiri Sasivimol, Jongkhajornpong Passara
Department of Ophthalmology, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clin Ophthalmol. 2020 Oct 23;14:3487-3494. doi: 10.2147/OPTH.S278701. eCollection 2020.
To assess the repeatability of anterior segment parameters and axial length (AL) using Pentacam AXL and Galilei G6 and the agreement between both devices.
Eighty-four eyes of 84 participants were measured prospectively with two devices. Outcome measurements included corneal curvatures, anterior chamber depth (ACD), AL, pupil size, and white-to-white distance (WTW). Intra-device repeatability was assessed using intraclass correlation coefficient (ICC), within-subject standard deviation (Sw), test-re-test repeatability (TRT=2.77 Sw), and coefficient of variation (CoV). Agreement between two devices was analyzed using Bland-Altman plots.
For each device, the Sw of corneal curvatures, ACD, and AL were lower than 0.25 D, 0.04 mm, and 0.04 mm, respectively. The ICC was higher than 0.90 in all parameters measured by Pentacam AXL, whereas three parameters measured by Galilei G6 (steep meridian at anterior and posterior cornea, and pupil size) were lower than 0.90. Comparing to Galilei G6, Pentacam AXL led to significantly lower mean anterior cornea curvatures (Km) with the mean difference (95% level of agreement; LoA) of -0.12 D (-0.36, 0.12, <0.001). For ACD, there was no significant difference between the two devices. Pentacam AXL led to significantly lower AL, pupil size, and WTW, with the mean differences (95% LoA) of -0.04 mm (-0.35, 0.27), -0.18 mm (-0.71, 0.35), and -0.35 mm (-0.61, -0.10), respectively.
We found good repeatability of corneal curvature, ACD, and AL in both devices. Most parameters obtained from Pentacam AXL were statistically significantly different from those obtained from Galilei G6, except for steep meridians and ACD.
使用Pentacam AXL和Galilei G6评估眼前节参数和眼轴长度（AL）的可重复性以及两种设备之间的一致性。
前瞻性地使用两种设备对84名参与者的84只眼睛进行测量。测量结果包括角膜曲率、前房深度（ACD）、眼轴长度、瞳孔大小和白对白距离（WTW）。使用组内相关系数（ICC）、受试者内标准差（Sw）、重测重复性（TRT = 2.77 Sw）和变异系数（CoV）评估设备内部的可重复性。使用Bland-Altman图分析两种设备之间的一致性。
对于每种设备，角膜曲率、ACD和AL的Sw分别低于0.25 D、0.04 mm和0.04 mm。Pentacam AXL测量的所有参数的ICC均高于0.90，而Galilei G6测量的三个参数（角膜前后表面的陡峭子午线和瞳孔大小）低于0.90。与Galilei G6相比，Pentacam AXL导致平均角膜前表面曲率（Km）显著降低，平均差异（95%一致性界限；LoA）为-0.12 D（-0.36，0.12，<0.001）。对于ACD，两种设备之间没有显著差异。Pentacam AXL导致眼轴长度、瞳孔大小和白对白距离显著降低，平均差异（95% LoA）分别为-0.04 mm（-0.35，0.27）、-0.18 mm（-0.71，0.35）和-0.35 mm（-0.61，-0.10）。
我们发现两种设备中角膜曲率、ACD和AL具有良好的可重复性。除了陡峭子午线和ACD外，Pentacam AXL获得的大多数参数与Galilei G6获得的参数在统计学上有显著差异。
