Ruan Xiaoting, Yang GuangYao, Xia Zhaoxia, Zhang Jiaqing, Gu Xiaoxun, Tan Yuan, Liu Zhenzhen, Luo Lixia
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Front Med (Lausanne). 2022 Feb 11;9:777443. doi: 10.3389/fmed.2022.777443. eCollection 2022.
To compare the difference and agreement in central corneal thickness (CCT), keratometry (K), anterior chamber depth (ACD), aqueous depth (AQD), and lens thickness (LT) measured with CASIA 2 and IOLMaster 700 in patients with cataract.
A total of 81 patients with cataract (81 eyes) scheduled for phacoemulsification were prospectively collected from March to May, 2020 in the cataract department of Zhongshan Ophthalmic Center, Sun Yat-sen University, including 43 males and 38 females with age of 61.5 ± 10.6 years. CCT, anterior K, anterior K, real K, real K, ACD, AQD, and LT were measured with CASIA 2 and IOLMaster 700. Paired -test, intraclass correlation coefficients (ICCs), 95% limit of agreement (95% LoA), and Bland-Altman plots were performed and used to analyze the difference and agreement between the two devices.
There was no statistically significant difference in anterior K measurement with the CASIA 2 (44.3 ± 1.66 mm) and IOLMaster 700 (44.31 ± 1.67 mm, = 0.483). Differences among the CCT, anterior K, real K, real K, ACD, AQD, and LT measured by the two instruments were statistically significant ( < 0.001). The ICCs of CCT, anterior K, anterior K, real K, real K, ACD, AQD, and LT measurements between the two devices were 0.892, 0.991, 0.991, 0.827, 0.817, 0.937, 0.926, and 0.997, respectively. The 95% LoA between CASIA 2 and IOLMaster 700 was -30.06 to 0.43 μm for CCT, -0.3 to 0.48 D for anterior Kf, -0.46 to -0.43 D for anterior Ks, -1.49 to -0.49 D for real Kf, -1.62 to -0.49 D for Real Ks, -0.03 to 0.24 mm for ACD, 0.04 to 0.25 mm for AQD, and -0.06 to 0.09 mm for LT.
Anterior K, anterior K, ACD, AQD, and LT have excellent agreement between the two devices. CCT, real K, and real K have moderate agreement between the two devices. It is recommended to use anterior K, anterior Ks, ACD, AQD, and LT interchangeably between CASIA 2 and IOLMaster 700.
比较使用CASIA 2和IOLMaster 700测量白内障患者中央角膜厚度（CCT）、角膜曲率（K）、前房深度（ACD）、房水深度（AQD）和晶状体厚度（LT）的差异及一致性。
2020年3月至5月，中山大学中山眼科中心白内障科前瞻性收集了81例计划行超声乳化白内障吸除术的白内障患者（81只眼），其中男性43例，女性38例，年龄61.5±10.6岁。使用CASIA 2和IOLMaster 700测量CCT、前表面K、前表面K、实际K、实际K、ACD、AQD和LT。采用配对t检验、组内相关系数（ICC）、95%一致性界限（95% LoA）和Bland-Altman图分析两种设备之间的差异和一致性。
CASIA 2测量的前表面K（44.3±1.66 mm）与IOLMaster 700测量的前表面K（44.31±1.67 mm，P = 0.483）无统计学显著差异。两种仪器测量的CCT、前表面K、实际K、实际K、ACD、AQD和LT之间的差异有统计学意义（P < 0.001）。两种设备之间CCT、前表面K、前表面K、实际K、实际K、ACD、AQD和LT测量的ICC分别为0.892、0.991、0.991、0.827、0.817、0.937、0.926和0.997。CASIA 2和IOLMaster 700之间CCT的95% LoA为-30.06至0.43μm，前表面Kf为-0.3至0.48 D，前表面Ks为-0.46至-0.43 D，实际Kf为-1.49至-0.49 D，实际Ks为-1.62至-0.49 D，ACD为-0.03至0.24 mm，AQD为0.04至0.25 mm，LT为-0.06至0.09 mm。
两种设备在前表面K、前表面Ks、ACD、AQD和LT方面具有良好的一致性。CCT、实际K和实际K两者之间具有中等一致性。建议在CASIA 2和IOLMaster 700之间可互换使用前表面K、前表面Ks、ACD、AQD和LT。
