滑石粉会阴部使用与卵巢癌风险之间关联的批判性回顾。
Critical review of the association between perineal use of talc powder and risk of ovarian cancer.
机构信息
Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
出版信息
Reprod Toxicol. 2019 Dec;90:88-101. doi: 10.1016/j.reprotox.2019.08.015. Epub 2019 Aug 28.
UNLABELLED
Over the past four decades, there has been increasing concern that perineal use of talc powder, a commonly used personal care product, might be associated with an increased risk of ovarian cancer.
OBJECTIVES
To critically review all available human epidemiological data on the relationship between perineal use of talc powder and ovarian cancer, with consideration of other relevant experimental evidence.
METHODOLOGY
We identified 30 human studies for qualitative assessment of evidence, including 27 that were retained for further quantitative analysis.
RESULTS
A positive association between perineal use of talc powder and ovarian cancer was found [OR: 1.28 (95% CI: 1.20-1.37)]. A significant risk was noted in Hispanics and Whites, in women applying talc to underwear, in pre-menopausal women and in post-menopausal women receiving hormonal therapy. A negative association was noted with tubal ligation.
CONCLUSION
Perineal use of talc powder is a possible cause of human ovarian cancer.
目的
批判性地回顾所有关于滑石粉会阴使用与卵巢癌之间关系的可用人体流行病学数据，并考虑其他相关的实验证据。
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