Zhang Yana, Liu Wenxin, Li Yongjun, Yang Ying-Wei, Dong Alideertu, Li Yuliang
College of Chemistry and Chemical Engineering, Inner Mongolia University, 235 University West Street, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education,Inner Mongolia University, 235 University West Street, Hohhot 010021, China.
Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, No. 2 North First Street, Zhongguancun, Beijing 100190, China.
iScience. 2019 Sep 27;19:662-675. doi: 10.1016/j.isci.2019.08.019. Epub 2019 Aug 16.
Graphdiyne (GDY) as an emerging 2D carbon-network nanomaterial possesses many fascinating properties that lead to numerous exciting applications, but the use of GDY and its derivatives in the antibacterial field has not yet been discovered. In this study, we first report on the use and evaluation of GDY and graphdiyne oxide (GDYO) as antibacterial agents and propose the antibacterial mechanisms of GDY-based nanomaterials. GDYO has been synthesized via the surface oxidation of GDY, and the antibacterial activity of GDYO has been compared with that of GDY through a series of antibacterial tests. Surprisingly, surface oxidation endowed inert GDY with superior antibacterial capability against two representative bacterial models: Escherichia coli and Staphylococcus aureus. Antibacterial mechanism experiments disclose that the antibacterial function of GDYO is a result of reactive oxygen species-dependent oxidation stress when a dispersed GDYO suspension has a direct contact with bacteria especially under visible light irradiation.
石墨炔（GDY）作为一种新兴的二维碳网络纳米材料，具有许多引人入胜的特性，从而带来了众多令人兴奋的应用，但石墨炔及其衍生物在抗菌领域的应用尚未被发现。在本研究中，我们首次报道了石墨炔和氧化石墨炔（GDYO）作为抗菌剂的使用和评估，并提出了基于石墨炔的纳米材料的抗菌机制。通过石墨炔的表面氧化合成了GDYO，并通过一系列抗菌测试将GDYO的抗菌活性与石墨炔进行了比较。令人惊讶的是，表面氧化赋予了惰性石墨炔对两种代表性细菌模型——大肠杆菌和金黄色葡萄球菌——卓越的抗菌能力。抗菌机制实验表明，当分散的GDYO悬浮液与细菌直接接触时，尤其是在可见光照射下，GDYO的抗菌功能是活性氧依赖性氧化应激的结果。
