MAP4K4 通过与 BIK1 相互作用来调节植物先天免疫。
MAP4K4 associates with BIK1 to regulate plant innate immunity.
机构信息
Desert Agriculture Initiative, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
出版信息
EMBO Rep. 2019 Nov 5;20(11):e47965. doi: 10.15252/embr.201947965. Epub 2019 Sep 2.
Abstract
To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
摘要
为了感知病原体，植物利用模式识别受体（PRR）复合物，然后通过受体样细胞质激酶 BIK1 传递这些信号，以诱导防御反应。然而，BIK1 的活性和稳定性如何被控制仍不完全清楚。在这里，我们表明 Hippo/STE20 同源物 MAP4K4 调节 BIK1 介导的免疫反应。MAP4K4 与 BIK1 结合并在 Ser233、Ser236 和 Thr242 处磷酸化 BIK1，以确保 BIK1 的稳定性和活性。此外，MAP4K4 磷酸化 PP2C38 的 Ser77，以实现 flg22 诱导的 BIK1 激活。我们的结果揭示了 Hippo/STE20 同源物 MAP4K4 维持中央免疫成分 BIK1 的内稳态。
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