N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Faculty of Biology, Moscow State University, Moscow, Russia.
J Immunol Res. 2019 Jul 29;2019:1394191. doi: 10.1155/2019/1394191. eCollection 2019.
Recent research on cancer-associated microbial communities led to the accumulation of data on the interplay between bacteria, immune and tumor cells, the pathways of bacterial induction of carcinogenesis, and its meaningfulness for medicine. Microbial communities that have any kind of impact on tumor progression and microorganisms associated with tumors have been defined as oncobiome. Over the last decades, a number of studies were dedicated to and its role in the progression of stomach tumors, so this correlation can be regarded as proven. Involvement of bacteria in the induction of lung cancer has been largely ignored for a long time, though some correlations between this type of cancer and lung microbiome were established. Despite the fact that in the present the microbial impact on lung cancer progression has many confirmations, the underlying mechanisms are poorly understood. Microorganisms can contribute to tumor initiation and progression through production of bacteriotoxins and other proinflammatory factors. The purpose of this review is to organize the available data on lung cancer microbiome and its role in malignant tumor progression.
最近关于癌症相关微生物群落的研究积累了关于细菌、免疫和肿瘤细胞之间相互作用的数据，包括细菌诱导致癌的途径及其对医学的意义。对肿瘤进展有任何影响的微生物群落和与肿瘤相关的微生物被定义为oncobiome。在过去的几十年里，许多研究致力于胃肿瘤进展中的作用及其作用，因此可以认为这种相关性已经得到证实。尽管已经证实了微生物对肺癌进展的影响，但长期以来，细菌在肺癌诱导中的作用在很大程度上被忽视了，尽管已经确定了这种癌症与肺部微生物组之间的一些相关性。尽管目前微生物对肺癌进展的影响有许多证实，但潜在的机制仍不清楚。微生物可以通过产生细菌毒素和其他促炎因子来促进肿瘤的发生和发展。本综述的目的是整理关于肺癌微生物组及其在恶性肿瘤进展中的作用的现有数据。
