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Potential for False-Positive Results with Serological Assays for HIV in Central Africa: Implications for the HIV Serodiagnosis Algorithm According to the 2015 Consolidated WHO Recommendations for Resource-Constrained Countries.中非地区HIV血清学检测出现假阳性结果的可能性：根据世界卫生组织2015年针对资源有限国家的综合建议对HIV血清学诊断算法的影响
AIDS Res Hum Retroviruses. 2017 Nov;33(11):1077-1079. doi: 10.1089/AID.2017.0059. Epub 2017 Aug 16.
2
Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws.梅毒和雅司病联合梅毒螺旋体及非梅毒螺旋体快速诊断试验性能的Meta分析
Clin Infect Dis. 2016 Sep 1;63(5):627-633. doi: 10.1093/cid/ciw348. Epub 2016 May 23.
3
Recent trends in the serologic diagnosis of syphilis.梅毒血清学诊断的近期趋势
Clin Vaccine Immunol. 2015 Feb;22(2):137-47. doi: 10.1128/CVI.00681-14. Epub 2014 Nov 26.
4
Association of inconclusive sera for human immunodeficiency virus infection with malaria and Epstein-Barr virus infection in Central Africa.中部非洲地区人类免疫缺陷病毒感染不确定血清与疟疾和 Epstein-Barr 病毒感染的相关性。
J Clin Microbiol. 2014 Feb;52(2):660-2. doi: 10.1128/JCM.02945-13. Epub 2013 Dec 4.
5
Causes of false-positive HIV rapid diagnostic test results.HIV 快速诊断检测假阳性结果的原因。
Expert Rev Anti Infect Ther. 2014 Jan;12(1):49-62. doi: 10.1586/14787210.2014.866516.
6
Usefulness in clinical practice of a point-of-care rapid test for simultaneous detection of nontreponemal and Treponema pallidum-specific antibodies in patients suffering from documented syphilis.即时检测快速试验在临床实践中对确诊梅毒患者同时检测非梅毒螺旋体和梅毒螺旋体特异性抗体的实用性。
Int J STD AIDS. 2013 Dec;24(12):944-50. doi: 10.1177/0956462413487328. Epub 2013 Sep 1.
7
Novel point-of-care test for simultaneous detection of nontreponemal and treponemal antibodies in patients with syphilis.新型即时检测法可同时检测梅毒患者的非梅毒螺旋体和梅毒螺旋体抗体。
J Clin Microbiol. 2010 Dec;48(12):4615-9. doi: 10.1128/JCM.00624-10. Epub 2010 Sep 29.
8
Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex.免疫遗传学与传染病：特别提及主要组织相容性复合体
Braz J Infect Dis. 2006 Apr;10(2):122-31. doi: 10.1590/s1413-86702006000200010.
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Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci.HLA I类基因座的等位基因和单倍型的多样性证明了非洲人群之间的差异。
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10
Western blot seroindeterminate individuals for human T-lymphotropic virus I/II (HTLV-I/II) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach.巴西福塔雷萨市人类嗜T淋巴细胞病毒I/II（HTLV-I/II）免疫印迹血清学检测不确定个体：血清学、分子诊断及流行病学研究方法
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免疫层析双梅毒快速检测中种族和环境对非梅毒螺旋体和梅毒螺旋体抗原不确定反应性的差异影响

Differential influence of race and environment on indeterminate reactivities to non-treponemal and treponemal antigens by immuno-chromatographic dual syphilis rapid test.

作者信息

Mbopi-Keou Francois-Xavier, Kalla Ginette Claude Mireille, Voundi Esther Voundi, Jenabian Mohammad-Ali, Mboumba Bouassa Ralph-Sydney, Talla Frédéric, Angwafo Fru F, Belec Laurent

机构信息

University of Yaounde I, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon.

The Institute for the Development of Africa (The-IDA), Yaoundé, Cameroon.

出版信息

Pan Afr Med J. 2019 Jun 6;33:90. doi: 10.11604/pamj.2019.33.90.16437. eCollection 2019.

DOI:10.11604/pamj.2019.33.90.16437
PMID:31489068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6711684/
Abstract

INTRODUCTION

Syphilis rapid test results may be influenced by numerous environmental and genetic factors.

METHODS

The proportion of false positive syphilis non-treponemal (NT) and treponemal (T) test results using immuno-chromatographic dual syphilis rapid test on serum from Cameroonian blacks (n=103) versus French blacks (n=104) or French caucasians (n=51), all HIV-negative and free of clinical syphilis, was examined.

RESULTS

Black individuals in Cameroon had a significantly higher frequency of false positive NT or T tests than black individuals in France. black individuals in France had a higher frequency of indeterminate NT tests as compared to caucasians in France.

CONCLUSION

Both racial and environmental factors may affect immuno-chromatographic dual syphilis rapid testing.

摘要

引言

梅毒快速检测结果可能受到众多环境和遗传因素的影响。

方法

对喀麦隆黑人（n = 103）、法国黑人（n = 104）或法国高加索人（n = 51）的血清进行免疫层析双梅毒快速检测，所有受试者均为HIV阴性且无临床梅毒，检查梅毒非梅毒螺旋体（NT）和梅毒螺旋体（T）检测结果的假阳性比例。

结果

喀麦隆的黑人NT或T检测假阳性频率显著高于法国的黑人。与法国的高加索人相比，法国的黑人NT检测不确定频率更高。

结论

种族和环境因素均可能影响免疫层析双梅毒快速检测。