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致病性酵母克鲁斯假丝酵母的细胞甘露聚糖的新结构

Novel structure of the cellular mannan of the pathogenic yeast Candida krusei.

作者信息

Kogan G, Pavliak V, Sandula J, Masler L

机构信息

Institute of Chemistry, Slovak Academy of Sciences, Bratislava.

出版信息

Carbohydr Res. 1988 Dec 31;184:171-82. doi: 10.1016/0008-6215(88)80015-6.

DOI:10.1016/0008-6215(88)80015-6
PMID:3149545
Abstract

On the basis of methylation analysis, 13C- and 1H-n.m.r. spectroscopic data, and the results of immunological methods, a new structure for the cell-wall alpha-D-mannan of the pathogenic yeast Candida krusei is proposed. In contrast to the alpha-D-mannans of other pathogenic yeasts of the Candida species, which have (1----6)-linked main chains and many (1----2)- and/or (1----3)-linked side chains, the C. krusei mannan is lightly branched and contains (1----2) and (1----6) linkages in the ratio 3:1.

摘要

基于甲基化分析、碳-13和氢-1核磁共振光谱数据以及免疫学方法的结果,提出了致病酵母克鲁斯念珠菌细胞壁α-D-甘露聚糖的新结构。与念珠菌属其他致病酵母的α-D-甘露聚糖不同,后者具有(1→6)连接的主链和许多(1→2)和/或(1→3)连接的侧链,克鲁斯念珠菌甘露聚糖分支较少,且(1→2)和(1→6)连接的比例为3:1。

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