University of Ulm, Institute of Evolutionary Ecology and Conservation Genomics, Ulm, Germany.
Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate member of Free University, Humboldt-University and Berlin Institute of Health, Berlin, Germany.
Sci Rep. 2019 Sep 16;9(1):13410. doi: 10.1038/s41598-019-49829-z.
Adenovirus (AdV) infections are one of the main causes of diarrhea in young children. Enteric AdVs probably disrupt gut microbial defences, which can result in diarrhea. To understand the role of the gut microbiome in AdV-induced pathologies, we investigated the gut microbiome of a naturally AdV-infected non-human primate species, the Malagasy mouse lemur (Microcebus griseorufus), which represents an important model in understanding the evolution of diseases. We observed that AdV infection is associated with disruption of the gut microbial community composition. In AdV+ lemurs, several commensal taxa essential for a healthy gut microbiome decreased, whereas genera containing potential pathogens, such as Neisseria, increased in abundance. Microbial co-occurrence networks revealed a loss of important microbial community interactions in AdV+ lemurs and an overrepresentation of Prevotellaceae. The observation of enteric virus-associated loss of commensal bacteria and associated shifts towards pathobionts may represent the missing link for a better understanding of AdV-induced effects in humans, and also for their potential as drivers of co-infections, an area of research that has been largely neglected so far.
腺病毒（AdV）感染是导致幼儿腹泻的主要原因之一。肠道 AdV 可能破坏肠道微生物防御系统，从而导致腹泻。为了了解肠道微生物组在 AdV 诱导的病理中的作用，我们研究了一种自然感染 AdV 的非人类灵长类物种——马达加斯加鼠狐猴（Microcebus griseorufus）的肠道微生物组，它是理解疾病进化的重要模型。我们观察到 AdV 感染与肠道微生物群落组成的破坏有关。在 AdV+狐猴中，几种对健康肠道微生物组至关重要的共生菌群减少，而包含潜在病原体的属，如奈瑟菌属，丰度增加。微生物共现网络显示，AdV+狐猴中重要的微生物群落相互作用丧失，普雷沃氏菌科过度表达。肠道病毒相关的共生菌丧失和向条件致病菌的转变可能代表了更好地理解 AdV 诱导的人类效应的缺失环节，也代表了它们作为共感染驱动因素的潜力，这一研究领域迄今为止在很大程度上被忽视了。
