College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.
Theranostics. 2019 Aug 12;9(20):5828-5838. doi: 10.7150/thno.34837. eCollection 2019.
Hepatocellular carcinoma (HCC) has been reported to be the third most common malignant tumor and has the highest rate of mortality. To increase the chemotherapy efficacy of HCC, a drug delivery system featured with desirable active targeting ability, delivery efficiency and immune evasion is in high demand. We have developed a drug nanocarrier by utilizing a homotypic cancer cell membrane for targeted chemotherapy of HCC. Structurally, the homotypic HepG2 cell membrane was used as the cloak, and a poly (lactic--glycolic acid) (PLGA) nanoparticle as the core, resulting in the nanocarrier . The nanoparticles exhibit excellent targeting ability toward HepG2 cells. Doxorubicin (Dox) carried by possesses high delivery efficiency and a remarkable therapeutic effect. In experiments, delivers Dox directly to the tumor lesion of nude mice, and tumor volume decreases by approximately 90% after treatment. We have developed a drug nanocarrier by utilizing a homotypic cancer cell membrane for targeted chemotherapy of HCC with excellent active targeting ability. This biomimetic platform not only effectively treats HCC but also provides a sound strategy for the treatment of other cancers changes in the corresponding homotypic cancer cell membrane.
肝细胞癌（HCC）已被报道为第三大常见恶性肿瘤，其死亡率最高。为了提高 HCC 的化疗疗效，需要一种具有理想的主动靶向能力、递药效率和免疫逃逸能力的药物递送系统。我们利用同源癌细胞膜开发了一种用于 HCC 靶向化疗的药物纳米载体。在结构上，同源 HepG2 细胞膜被用作伪装，聚乳酸-羟基乙酸共聚物（PLGA）纳米颗粒作为核心，形成纳米载体。该纳米颗粒对 HepG2 细胞具有优异的靶向能力。携带的阿霉素（Dox）具有高递药效率和显著的治疗效果。在实验中，该纳米载体直接将 Dox 递送至裸鼠的肿瘤病变部位，治疗后肿瘤体积减少约 90%。我们利用同源癌细胞膜开发了一种用于 HCC 靶向化疗的药物纳米载体，具有优异的主动靶向能力。这种仿生平台不仅能有效治疗 HCC，还为治疗其他癌症提供了一种合理的策略，即通过改变相应的同源癌细胞膜。
