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用于猪病病毒检测的光子生物传感器的设计与开发。

Design and Development of Photonic Biosensors for Swine Viral Diseases Detection.

机构信息

Universitat Politècnica de València Nanophotonics Technology Center, 46022 València, Spain.

Lumensia Sensors S.L., 46022 València, Spain.

出版信息

Sensors (Basel). 2019 Sep 15;19(18):3985. doi: 10.3390/s19183985.

DOI:10.3390/s19183985
PMID:31540156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6766991/
Abstract

In this paper we introduce a field diagnostic device based on the combination of advanced bio-sensing and photonics technologies, to tackle emerging and endemic viruses causing swine epidemics, and consequently significant economic damage in farms. The device is based on the use of microring resonators fabricated in silicon nitride with CMOS compatible techniques. In the paper, the designed and fabricated photonic integrated circuit (PIC) sensors are presented and characterized, showing an optimized performance in terms of optical losses (30 dB per ring) and extinction ration for ring resonances (15 dB). Furthermore, the results of an experiment for porcine circovirus 2 (PCV2) detection by using the developed biosensors are presented. Positive detection for different virus concentrations has been obtained. The device is currently under development in the framework of the EU Commission co-funded project SWINOSTICS.

摘要

本文介绍了一种基于先进生物传感和光子学技术结合的现场诊断设备，用于应对引起猪群流行并造成农场重大经济损失的新兴和地方性病毒。该设备基于使用氮化硅制造的微环谐振器，并采用与 CMOS 兼容的技术。本文介绍并分析了所设计和制造的光子集成电路 (PIC) 传感器，其在环形谐振器的光学损耗（每个环 30dB）和消光比（15dB）方面表现出了优化的性能。此外，还展示了使用所开发的生物传感器进行猪圆环病毒 2 (PCV2) 检测的实验结果。已获得针对不同病毒浓度的阳性检测结果。该设备目前正在欧盟委员会共同资助的项目 SWINOSTICS 的框架下进行开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/53035b7796c4/sensors-19-03985-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/ab483360471f/sensors-19-03985-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/b6acf3339896/sensors-19-03985-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/adef8860fc43/sensors-19-03985-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/e16574907cf8/sensors-19-03985-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/02448499a95b/sensors-19-03985-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/614e326d8cc2/sensors-19-03985-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/017ac1375f09/sensors-19-03985-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/53035b7796c4/sensors-19-03985-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/ab483360471f/sensors-19-03985-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/b6acf3339896/sensors-19-03985-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/adef8860fc43/sensors-19-03985-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/e16574907cf8/sensors-19-03985-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/02448499a95b/sensors-19-03985-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/614e326d8cc2/sensors-19-03985-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/017ac1375f09/sensors-19-03985-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a717/6766991/53035b7796c4/sensors-19-03985-g008.jpg

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