Division of Bioceramics, Sree Chitra Tirunal Institute for Medical Sciences & Technology, 695012, India; Department of Chemistry, M.E.S Asmabi College, P. Vemballur, Kodungallur 680671, India.
Materials Research Centre, Indian Institute of Science, Bangalore 560012, India.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110019. doi: 10.1016/j.msec.2019.110019. Epub 2019 Jul 26.
Commercially available titanium (Ti) having high mechanical strength and a low area of cross-section can be adequately exploited for minimally invasive dental implantation. Current directions in clinical dental implant therapy focus on endosseous dental implant surfaces with nanoscale topographies using easy and economical processing approaches. The present study describes the generation of a novel nanolayer nucleating agent on the surface of Ti implant for early endosseous after implantation. The strategy is to modify the surface of Ti implant using Ca(OH) via hydrothermal technique (Ti-HT). The X-ray photoelectron spectroscopy analysis confirmed the presence of chemically bonded Ca ions on the Ti surface in the form of CaTiO. In vitro studies are carried out to confirm the bone bonding ability of calcium enriched Ti surface. The apatite deposition on the surface after exposure to SBF for 7 days is confirmed via scanning electron microscopy, X-ray powder diffraction, Fourier-transform infrared spectroscopy and energy-dispersive X-ray spectroscopy techniques. The cell viability of Ti-HT was evaluated using direct contact method and MTT assay. The potential of Ca ion on Ti surface via hydrothermal pre-treatment to enhance osseointegration of Ti has been proposed for achieving early stability for dental implants.
商业上可用的钛（Ti）具有高强度和小的横截面积，可以充分用于微创牙科植入。目前临床牙科植入物治疗的方向侧重于使用简单经济的处理方法，在纳米尺度上对骨内牙科植入物表面进行处理。本研究描述了在植入后的早期骨内阶段，在 Ti 植入物表面生成新型纳米层成核剂的方法。该策略是通过水热技术（Ti-HT）用 Ca(OH)2 对 Ti 植入物表面进行改性。X 射线光电子能谱分析证实了 Ti 表面上以 CaTiO3 的形式存在化学结合的 Ca 离子。进行体外研究以确认富含钙的 Ti 表面的骨结合能力。通过扫描电子显微镜、X 射线粉末衍射、傅里叶变换红外光谱和能谱技术确认了在 SBF 暴露 7 天后表面上的磷灰石沉积。使用直接接触法和 MTT 测定法评估 Ti-HT 的细胞活力。通过水热预处理在 Ti 表面上施加 Ca 离子以增强 Ti 的骨整合的潜力，已被提出用于实现牙科植入物的早期稳定性。
