Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.
Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 1Y6, Canada.
Viruses. 2019 Sep 21;11(10):886. doi: 10.3390/v11100886.
For the first 60 years following its isolation, Zika virus (ZIKV) remained a relatively poorly described member of the family. However, since 2007, it has caused a series of increasingly severe outbreaks and is now associated with neurological symptoms such as Guillain-Barré syndrome and congenital Zika syndrome (CZS). A number of reports have improved our understanding of rare complications that may be associated with ZIKV infection in adults, the areas of the body to which it spreads, and viral persistence in various tissues. Likewise, studies on the effect of ZIKV infection during pregnancy have identified risk factors for CZS and the impact this syndrome has on early childhood. Understanding these outcomes and the factors that drive ZIKV pathogenesis are key to developing vaccination and therapeutic approaches to avoid these severe and potentially debilitating symptoms.
寨卡病毒（ZIKV）在被分离出来后的最初 60 年里，一直是一种描述相对较少的病毒。然而，自 2007 年以来，它引发了一系列越来越严重的疫情爆发，并与吉兰-巴雷综合征和先天性寨卡综合征（CZS）等神经系统症状有关。许多报告提高了我们对成人感染寨卡病毒可能相关的罕见并发症、病毒传播的身体部位以及各种组织中病毒持续存在的理解。同样，对妊娠期寨卡病毒感染影响的研究确定了 CZS 的风险因素，以及该综合征对儿童早期的影响。了解这些结果以及导致寨卡病毒发病机制的因素，是开发疫苗和治疗方法以避免这些严重且可能使人衰弱的症状的关键。
