多种介孔二氧化硅纳米颗粒作为药物左旋多巴有效载体的效能
Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA.
作者信息
Swar Sumita, Máková Veronika, Stibor Ivan
机构信息
Department of Nanomaterials in Natural Science, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 46117 Liberec, Czech Republic.
出版信息
Materials (Basel). 2019 Sep 30;12(19):3202. doi: 10.3390/ma12193202.
Our study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson's disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle.
我们的研究集中于合成用于药物递送且被广泛研究的选择性介孔二氧化硅纳米颗粒（MSNs：MCM - 41、MCM - 48、SBA - 15、PHTS、MCF）。利用经过验证的合成程序方便地制备出了所得的介孔表面。通过布鲁诺尔-埃米特-泰勒（BET）分析和扫描电子显微镜（SEM）对如此获得的MSNs进行了表征。对具有不同孔径和形态的选定MSNs进行了检测，以评估左旋多巴（L - DOPA）药物负载和释放的能力。L - DOPA是一种治疗帕金森病的知名药物。通过紫外可见光谱法测量了L - DOPA药物负载和释放曲线，并且在所有不同类型的测试介孔二氧化硅材料中，SBA - 15被证明是作为L - DOPA药物载体最有效的材料。
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