Traditional Chinese Medicine Department, Affiliated Hospital of Nankai University, Tianjin, China; Cardiology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Endocrinology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Biomed Pharmacother. 2019 Dec;120:109451. doi: 10.1016/j.biopha.2019.109451. Epub 2019 Oct 3.
The occurrence of ischemic heart disease(IHD) is a multi-step chain process from potential risk factors to overt clinical diseases. Vascular cells, blood cells, cardiomyocytes and stem cells are all involved in the pathophysiological links via continual and polynary crosstalk. Exosomes,as powerful vectors for intercellular communication,have been a hotspot for basic and clinical research. Plenty of evidence has shown that exosomes largely participate in the evolution of IHD, including endothelial dysfunction, lipid deposition, atheromatous plaque formation and rupture, myocardial ischemia-reperfusion(I/R) injury,and heart failure (HF), while the rules for detailed communication in the different stages of this continuous disease are still poorly understood. This review will systematically describe characteristics of exosomal crosstalk between different cells in the diverse periods, and also cast light on the potential and challenges for exosome application as therapeutic targets, hoping to offer supporting background for the following research.
缺血性心脏病（IHD）的发生是从潜在危险因素到明显临床疾病的多步骤链式过程。血管细胞、血细胞、心肌细胞和干细胞都通过持续和多元的串扰参与病理生理联系。外泌体作为细胞间通讯的强大载体，一直是基础和临床研究的热点。大量证据表明，外泌体在很大程度上参与了 IHD 的演变，包括内皮功能障碍、脂质沉积、动脉粥样硬化斑块形成和破裂、心肌缺血再灌注（I/R）损伤和心力衰竭（HF），而在这一连续疾病的不同阶段详细的沟通规则仍知之甚少。本综述将系统描述不同细胞之间外泌体串扰的特征，并探讨外泌体作为治疗靶点的应用潜力和挑战，希望为后续研究提供支持背景。
