Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
J Acquir Immune Defic Syndr. 2019 Dec 15;82(5):452-461. doi: 10.1097/QAI.0000000000002157.
Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization.
We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible. The representative terminology and criteria were extracted and analyzed.
Twenty-two terms and 73 criteria to define the condition were identified. The most frequent term was "immunological nonresponders" and the most frequent criterion was "CD4 T-cell count <350 cells/µL after ≥24 months of virologic suppression." Most criteria use CD4+ T-cell counts as a surrogate, either as an absolute value or as a change after a defined period of time [corrected]. Distinct values and time points were used. Only 9 of the 73 criteria were used by more than one independent research team. Herein we propose 2 criteria that could help to reach a consensus.
The high disparity in terms and criteria here reported precludes data aggregation and progression of the knowledge on this condition, because it renders impossible to compare data from different studies. This review will foster the discussion of terms and criteria to achieve a consensual definition.
用于分类未能达到满意 CD4 T 细胞计数的抗逆转录病毒治疗人群的术语和标准存在差异，需要进行修订和总结。
我们对 2009 年 1 月至 2018 年 9 月期间发表的英文原创研究文章进行了系统综述，这些文章包含了一套预定义的术语。最初检索到 1360 项研究，其中 103 项符合条件。提取并分析了有代表性的术语和标准。
确定了 22 个术语和 73 个定义该病症的标准。最常用的术语是“免疫无应答者”，最常用的标准是“病毒学抑制后≥24 个月时 CD4 T 细胞计数<350 个/µL”。大多数标准都将 CD4+T 细胞计数作为替代指标，无论是绝对值还是在规定时间段后的变化值[纠正]。使用了不同的数值和时间点。73 个标准中只有 9 个被一个以上的独立研究小组使用。在此，我们提出了两个有助于达成共识的标准。
此处报告的术语和标准差异很大，这妨碍了对该病症数据的汇总和知识的发展，因为这使得不可能比较来自不同研究的数据。本综述将促进术语和标准的讨论，以达成共识的定义。
