Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Department of Psychology, Neuroscience Center, Brigham Young University, Provo, UT, USA.
Trends Cogn Sci. 2019 Nov;23(11):938-951. doi: 10.1016/j.tics.2019.08.003. Epub 2019 Oct 6.
The hippocampus is critical for learning and memory, relying in part on pattern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory representations. In 2007, we designed the Mnemonic Similarity Task (MST), a modified object recognition memory task, to be highly sensitive to hippocampal function by placing strong demands on pattern separation. The MST is now a widely used behavioral task, repeatedly shown to be sensitive to age-related memory decline, hippocampal connectivity, and hippocampal function, with specificity to the DG. Here, we review the utility of the MST, its relationship to hippocampal function, its utility in detecting hippocampal-based memory alterations across the lifespan, and impairments associated with clinical pathology from a variety of disorders.
海马体对于学习和记忆至关重要，部分依赖于齿状回（DG）支持的模式分离过程，以防止重叠记忆表示的干扰。2007 年，我们设计了记忆相似性任务（MST），这是一种经过修改的物体识别记忆任务，通过对模式分离提出更高的要求，使其对海马体功能具有高度的敏感性。现在，MST 是一种广泛使用的行为任务，它被反复证明对与年龄相关的记忆衰退、海马体连接和海马体功能敏感，并且对 DG 具有特异性。在这里，我们回顾了 MST 的效用、它与海马体功能的关系、它在检测整个生命周期中基于海马体的记忆改变方面的效用，以及与各种疾病相关的临床病理损害。
