喹诺酮治疗对人体无细胞遗传学效应。
No cytogenetic effects of quinolone treatment in humans.
作者信息
Mitelman F, Kolnig A M, Strömbeck B, Norrby R, Kromann-Andersen B, Sommer P, Wadstein J
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):936-7. doi: 10.1128/AAC.32.6.936.
Abstract
Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion.
摘要
对31例接受治疗1至10周的患者的淋巴细胞进行了环丙沙星（每日500至2000毫克）和氧氟沙星（每日200毫克）的细胞遗传学效应研究。所有患者在治疗开始前采集用于细胞遗传学分析的血样，25例患者在治疗1周后采集，6例患者在治疗2周、4周、6周和10周后采集。在任何治疗组中均未发现染色体损伤效应。在每个采样时间点，所研究的每个细胞遗传学参数的平均畸变率和畸变总数均正常。
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