No cytogenetic effects of quinolone treatment in humans.
作者信息
Mitelman F, Kolnig A M, Strömbeck B, Norrby R, Kromann-Andersen B, Sommer P, Wadstein J
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):936-7. doi: 10.1128/AAC.32.6.936.
Abstract
Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion.
摘要
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本文引用的文献
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