[细胞因子白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α、白细胞介素-4的含量以及腹腔液中巨噬细胞CD86和CD163的表达水平与外阴子宫内膜异位症的严重程度呈负相关]
[The content of cytokines IL-6, IL-8, TNF-α, IL-4 and the level of expression in macrophages CD86 and CD163 in peritoneal fluid has a reverse correlation with the degree of severity of external genital endometriosis].
作者信息
Krasnyi A M, Sadekova A A, Sefihanov T G, Vtorushina V V, Krechetova E G, Khilkevich E G, Arakelyan A S, Pavlovich S V
机构信息
Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia; Koltsov Institute of Developmental Biology, Moscow, Russia.
Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia.
出版信息
Biomed Khim. 2019 Aug;65(5):432-436. doi: 10.18097/PBMC20196505432.
Concentrations of eight different cytokines and the level of expression of CD86 and CD163 macrophages were studied in peritoneal fluid in women with endometriosis. It was found that the concentration of both inflammatory (IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4) as well as the level of macrophage expression of the proinflammatory marker CD86 and anti-inflammatory marker CD163 increased in women with mild external genital endometriosis (1-2 stage), and did not differ from the control group in women with severe endometriosis (3-4 stage). The content of IL-2, IL-10, CM-CSF and IFN-γ in the peritoneal fluid of women with endometriosis did not differ significantly from the control group. The results of the study indicate that the development of external genital endometriosis may be based on insufficient both inflammatory and anti-inflammatory activity of macrophages in the peritoneal fluid.
研究了子宫内膜异位症女性腹腔液中八种不同细胞因子的浓度以及CD86和CD163巨噬细胞的表达水平。结果发现，轻度外阴子宫内膜异位症（1-2期）女性腹腔液中炎症细胞因子（IL-6、IL-8、TNF-α）和抗炎细胞因子（IL-4）的浓度以及促炎标志物CD86和抗炎标志物CD163的巨噬细胞表达水平均升高，而重度子宫内膜异位症（3-4期）女性与对照组相比无差异。子宫内膜异位症女性腹腔液中IL-2、IL-10、CM-CSF和IFN-γ的含量与对照组相比无显著差异。研究结果表明，外阴子宫内膜异位症的发生可能是基于腹腔液中巨噬细胞的炎症和抗炎活性不足。
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