希腊孕妇头发、羊水和血清样本中的有机氯污染物水平。一项队列研究。
Organochlorine pollutants' levels in hair, amniotic fluid and serum samples of pregnant women in Greece. A cohort study.
机构信息
Laboratory of Toxicology Science and Research, Medical School, University of Crete, Heraklion, Greece; Feto-Maternal Medicine Department, 1st Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, University of Athens, Greece.
Laboratory of Toxicology Science and Research, Medical School, University of Crete, Heraklion, Greece.
出版信息
Environ Toxicol Pharmacol. 2020 Jan;73:103279. doi: 10.1016/j.etap.2019.103279. Epub 2019 Oct 16.
Persistent organic pollutants are synthetic chemicals highly resistant to degradation with strong tendency to bioaccumulation. Assessment of human exposure to these compounds is crucial for public health protection, especially during vulnerable periods. The aim of the present cohort study was to evaluate the level of contamination to PCBs, o,p'- and p,p'-DDE, o,p' and p,p'-DDD, o,p' and p,p'-DDT and HCB in pregnant women. Hair, amniotic fluid and serum samples were collected and analyzed by HS-SPME-GCMS. The most detected analytes in amniotic fluids were p,p'-DDE, p,p'-DDD, o,p'-DDE and PCB101, in serum p,p'-DDE, HCB and PCB101 and in hair p,p'-DDE, HCB and PCB101. The levels of HCB and PCB101 in amniotic fluids were positively correlated with those in hair. Higher levels of DDDs and DDTs in hair samples and PCB28 in amniotic fluids were observed in smoker pregnant women. Gestation age was inversely proportional with the detected levels of PCB101 in all tested samples.
持久性有机污染物是高度抗降解且具有强烈生物累积趋势的合成化学品。评估人类暴露于这些化合物的程度对于保护公众健康至关重要，特别是在脆弱时期。本队列研究的目的是评估孕妇体内多氯联苯、o,p'-和 p,p'-DDE、o,p'和 p,p'-DDD、o,p'和 p,p'-DDT 和 HCB 的污染水平。采集头发、羊水和血清样本，并通过 HS-SPME-GCMS 进行分析。在羊水中检测到的最主要的分析物是 p,p'-DDE、p,p'-DDD、o,p'-DDE 和 PCB101，在血清中是 p,p'-DDE、HCB 和 PCB101，在头发中是 p,p'-DDE、HCB 和 PCB101。羊水中 HCB 和 PCB101 的水平与头发中的水平呈正相关。吸烟孕妇的头发样本中 DDDs 和 DDTs 以及羊水样本中的 PCB28 水平较高。在所有检测样本中，胎龄与 PCB101 的检出水平呈反比。
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