Laboratory for Neuronal Circuit Dynamics, Imperial College London, London, UK.
Nat Rev Neurosci. 2019 Dec;20(12):719-727. doi: 10.1038/s41583-019-0231-4. Epub 2019 Nov 8.
A central goal in neuroscience is to determine how the brain's neuronal circuits generate perception, cognition and emotions and how these lead to appropriate behavioural actions. A methodological platform based on genetically encoded voltage indicators (GEVIs) that enables the monitoring of large-scale circuit dynamics has brought us closer to this ambitious goal. This Review provides an update on the current state of the art and the prospects of emerging optical GEVI imaging technologies.
神经科学的一个核心目标是确定大脑的神经元回路如何产生感知、认知和情感，以及这些如何导致适当的行为动作。一个基于遗传编码电压指示剂 (GEVI) 的方法学平台，能够监测大规模的回路动力学，使我们更接近这个雄心勃勃的目标。本文综述了当前的最新技术状况和新兴的光学 GEVI 成像技术的前景。
