Department of Otolaryngology, Faculty of Medicine, Bozok University, Atatürk Yolu 7. Km, 66100, Yozgat, Turkey.
Department of Neurology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Eur Arch Otorhinolaryngol. 2020 Feb;277(2):469-473. doi: 10.1007/s00405-019-05717-w. Epub 2019 Nov 9.
The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population.
Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis and 50 healthy volunteers were enrolled into the study. Saccharin clearance test was performed on both groups and NMC time was measured. Data analysis was performed by SPSS version 24.0 statistics program (SPSS Inc., Chicago, Illinois, USA). Statistical tests were interpreted at p < 0.05 significance level.
The NMC time averages in MS patients and healthy control group were 12.43 ± 4.05 min and 8.14 ± 2.87 min, respectively; the difference between the groups was significant (p < 0.001). There was a statistically strong association between NMC time values and Expanded Disability Status Scale (EDSS) values in MS patients (r = 0.817, p < 0.001).
We found nasal mucociliary transport time longer in MS patients than healthy population in the present study. To the best of our knowledge, there is not any study conducted about this topic in the literature. We believe that our findings would shed a light on further studies.
本研究旨在测量多发性硬化症（MS）患者的鼻黏液纤毛清除（NMC）时间，并将其与健康人群进行比较。
共纳入 97 名个体，包括 47 名复发缓解型多发性硬化症患者和 50 名健康志愿者。对两组均进行糖精清除试验，并测量 NMC 时间。数据分析采用 SPSS 24.0 统计程序（SPSS Inc.，芝加哥，伊利诺伊州，美国）进行。统计检验的显著性水平设为 p < 0.05。
MS 患者和健康对照组的 NMC 时间平均值分别为 12.43 ± 4.05 分钟和 8.14 ± 2.87 分钟，两组间差异有统计学意义（p < 0.001）。MS 患者的 NMC 时间值与扩展残疾状况量表（EDSS）值之间存在统计学上的强关联（r = 0.817，p < 0.001）。
在本研究中，我们发现 MS 患者的鼻黏液纤毛传输时间长于健康人群。据我们所知，目前文献中尚无关于此主题的研究。我们相信我们的发现将为进一步的研究提供启示。
