Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain.
Biomedical Research Center (CINBIO), University of Vigo, Vigo, Spain.
Nat Commun. 2019 Nov 13;10(1):5139. doi: 10.1038/s41467-019-12926-8.
How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic colonization, followed by a rapid population expansion at both primary and secondary sites. Moreover, we infer a hematogenous metastatic spread under positive selection, plus the return of some tumoral cells from the liver back to the colon lymph nodes. This study illustrates how sophisticated techniques typical of organismal evolution can provide a detailed, quantitative picture of the complex tumoral dynamics over time and space.
肿瘤克隆是如何以及何时开始扩散到周围和远处的组织目前尚不清楚。在这里，我们利用基于模型的进化框架来研究结直肠癌的种群历史和生物地理学历史。我们的分析强烈支持早期的克隆转移定植，随后在原发和继发部位迅速扩张。此外，我们推断出在正选择下的血源性转移扩散，以及一些肿瘤细胞从肝脏返回结肠淋巴结。这项研究说明了复杂的肿瘤动力学如何随着时间和空间的推移，通过典型的机体进化技术提供详细的定量图像。
