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使用单日表现测试识别大多数在延长清醒时间中表现受损风险较高的个体。

Using a Single Daytime Performance Test to Identify Most Individuals at High-Risk for Performance Impairment during Extended Wake.

机构信息

Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, 221 Longwood Avenue, Boston, MA, 02115, USA.

Division of Sleep Medicine, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.

出版信息

Sci Rep. 2019 Nov 13;9(1):16681. doi: 10.1038/s41598-019-52930-y.

DOI:10.1038/s41598-019-52930-y
PMID:31723161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6853981/
Abstract

We explored the predictive value of a neurobehavioral performance assessment under rested baseline conditions (evaluated at 8 hours awake following 8 hours of sleep) on neurobehavioral response to moderate sleep loss (evaluated at 20 hours awake two days later) in 151 healthy young participants (18-30 years). We defined each participant's response-to-sleep-loss phenotype based on the number of attentional failures on a 10-min visual psychomotor vigilance task taken at 20 hours awake (resilient: less than 6 attentional failures, n = 26 participants; non-resilient: 6 or more attentional failures, n = 125 participants). We observed that 97% of rested participants with 2 or more attentional failures (n = 73 of 151) and 100% of rested participants with 3 or more attentional failures (n = 57 of 151) were non-resilient after moderate sleep loss. Our approach can accurately identify a significant proportion of individuals who are at high risk for neurobehavioral performance impairment from staying up late with a single neurobehavioral performance assessment conducted during rested conditions. Additional methods are needed to predict the future performance of individuals who are not identified as high risk during baseline.

摘要

我们在 151 名健康的年轻参与者（18-30 岁）中，探索了在休息基线条件下（在 8 小时睡眠后清醒 8 小时进行评估）进行神经行为表现评估对中度睡眠剥夺后神经行为反应的预测价值（在两天后清醒 20 小时进行评估）。我们根据在清醒 20 小时时进行的 10 分钟视觉精神运动警戒任务中的注意力失败次数（resilient：少于 6 次注意力失败，n=26 名参与者；non-resilient：6 次或更多注意力失败，n=125 名参与者）来定义每个参与者的睡眠剥夺后反应表型。我们观察到，97%的在清醒时出现 2 次或更多注意力失败的参与者（n=73/151）和 100%的在清醒时出现 3 次或更多注意力失败的参与者（n=57/151）在中度睡眠剥夺后都属于非恢复性。我们的方法可以通过在休息条件下进行的单次神经行为表现评估，准确识别出大量因熬夜而导致神经行为表现受损风险较高的个体。需要额外的方法来预测在基线时未被确定为高风险的个体的未来表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/4b01702cbf21/41598_2019_52930_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/783b1a48612e/41598_2019_52930_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/070e0064f460/41598_2019_52930_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/4ff821e370b4/41598_2019_52930_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/19f1999755be/41598_2019_52930_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/7a950d440d2d/41598_2019_52930_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/b11096c2635a/41598_2019_52930_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/4b01702cbf21/41598_2019_52930_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/783b1a48612e/41598_2019_52930_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/070e0064f460/41598_2019_52930_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/20d93964df2f/41598_2019_52930_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/4ff821e370b4/41598_2019_52930_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/19f1999755be/41598_2019_52930_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/7a950d440d2d/41598_2019_52930_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/b11096c2635a/41598_2019_52930_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d6/6853981/4b01702cbf21/41598_2019_52930_Fig8_HTML.jpg

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