强直性脊柱炎、银屑病关节炎和银屑病中的抗核抗体。
Antinuclear antibodies in ankylosing spondylitis, psoriatic arthritis, and psoriasis.
作者信息
Rosenberg J N, Johnson G D, Holborow E J
出版信息
Ann Rheum Dis. 1979 Dec;38(6):526-8. doi: 10.1136/ard.38.6.526.
Abstract
Granulocyte-specific antinuclear antibodies (GS-ANA) were detected in the sera of 5 of 88 patients with ankylosing spondylitis (AS) and in 7 of 52 cases of psoriatic arthritis (PsA), but were not found in 91 patients with malignant or non-malignant chest disease nor in 25 cases of psoriasis. Organ non-specific ANA were present in serum from 6 cases of AS and 1 of PsA. None of the sera gave significant levels for soluble immune complexes as detected by a C1q-binding assay. The presence of antinuclear antibodies was not associated with clinical features or drug therapy in either AS or PsA.
摘要
在88例强直性脊柱炎（AS）患者的血清中，有5例检测到粒细胞特异性抗核抗体（GS-ANA）；在52例银屑病关节炎（PsA）患者的血清中，有7例检测到该抗体。但在91例恶性或非恶性胸部疾病患者以及25例银屑病患者的血清中未发现该抗体。6例AS患者和1例PsA患者的血清中存在器官非特异性ANA。通过C1q结合试验检测，所有血清中可溶性免疫复合物水平均无显著升高。在AS或PsA患者中，抗核抗体的存在与临床特征或药物治疗均无关联。
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