强直性脊柱炎的免疫反应性。循环免疫母细胞、自身抗体和免疫球蛋白。
Immunological reactivity in ankylosing spondylitis. Circulating immunoblasts, autoantibodies, and immunoglobulins.
作者信息
Eghtedari A A, Davis P, Bacon P A
出版信息
Ann Rheum Dis. 1976 Apr;35(2):155-7. doi: 10.1136/ard.35.2.155.
Abstract
Circulating immunoblasts were studied in 39 cases of ankylosing spondylitis. The results were compared with 20 normal subjects and a group of 39 patients with rheumatoid arthritis, Immunoblasts were found to be increased in 11 patients with ankylosing spondylitis and in 22 patients with rheumatoid arthritis in contrast to the controls who were found to have a normal lymphoid cell population in the peripheral blood. Fifteen patients showed raised levels of one or more class of immunoglobulin. Autoantibodies, including antinuclear factors, were negative in all cases. There was a correlation between raised immunoblasts and plasma viscosity but not with clinical assessment of activity. The increase of immunoblasts in the peripheral blood, together with the raised immunoglobulins supports the suggestion of an immunological basis for ankylosing spondylitis.
摘要
对39例强直性脊柱炎患者的循环免疫母细胞进行了研究。将结果与20名正常受试者以及39例类风湿关节炎患者进行了比较。与外周血淋巴细胞群体正常的对照组相比，发现11例强直性脊柱炎患者和22例类风湿关节炎患者的免疫母细胞增多。15例患者的一种或多种免疫球蛋白水平升高。包括抗核因子在内的自身抗体在所有病例中均为阴性。免疫母细胞升高与血浆粘度之间存在相关性，但与活动度的临床评估无关。外周血免疫母细胞增多以及免疫球蛋白升高支持强直性脊柱炎存在免疫学基础这一观点。
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