Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA.
Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO 80523, USA.
Nutrients. 2019 Nov 15;11(11):2780. doi: 10.3390/nu11112780.
Clinical studies indicate that eating common bean, L., plays a role in body weight regulation but mechanisms have yet to be elucidated. Here, we investigated the anti-obesogenic activity of white kidney bean in a mouse model of dietary-induced obesity. Bean consumption reduced the accumulation of adipose tissue in male and female C57BL6 mice. The anti-obesogenic effect of white kidney bean was not due to alterations in energy intake, energy excreted in the feces, or feed efficiency ratio. While bean consumption increased the mass of the intestine, no marked differences were consistently observed in crypt height, mucin content of goblet cells, proliferation index or zone of proliferation. However, significantly higher concentrations of total bacteria and of were detected in cecal content of bean-fed mice, and the ratio of Firmicutes to Bacteroidetes was reduced. Bile acid content was higher in the ileum of bean-fed mice, but transcript levels of farnesoid X receptor were not significantly affected. Whether changes in bile-acid-mediated cell signaling play a role in bean-related differences in fat accumulation and/or overall metabolic health requires further investigation.
临床研究表明，食用普通豆科植物（L.）在体重调节中发挥作用，但机制尚不清楚。在这里，我们研究了白芸豆在饮食诱导肥胖的小鼠模型中的抗肥胖作用。食用白芸豆可减少雄性和雌性 C57BL6 小鼠脂肪组织的堆积。白芸豆的抗肥胖作用不是由于能量摄入的改变、粪便中能量的排泄或饲料效率比的改变。虽然白芸豆的摄入增加了肠道的重量，但在隐窝高度、杯状细胞的粘蛋白含量、增殖指数或增殖区方面没有观察到一致的显著差异。然而，在白芸豆喂养的小鼠的盲肠内容物中检测到总细菌和的浓度显著升高，厚壁菌门与拟杆菌门的比例降低。白芸豆喂养的小鼠回肠中的胆汁酸含量较高，但法尼醇 X 受体的转录水平没有显著影响。胆汁酸介导的细胞信号转导的变化是否在白芸豆相关的脂肪堆积和/或整体代谢健康差异中发挥作用，需要进一步研究。
