脂质过氧化对心脏线粒体耗氧及钙转运能力的影响。
Effect of lipid peroxidation on heart mitochondria oxygen consuming and calcium transporting capacities.
作者信息
Ceconi C, Curello S, Albertini A, Ferrari R
机构信息
Universitá degli Studi di Brescia, Cattedra di Cardiologia e di Chimica, Brescia, Italy.
出版信息
Mol Cell Biochem. 1988 Jun;81(2):131-5. doi: 10.1007/BF00219315.
PMID:3173348
Abstract
The incubation of rabbit heart mitochondria in the presence of ferrous ions induced lipid peroxidation which was accompanied by a reduction of mitochondrial respiratory capacity and Ca++ transport. The effects were more evident, when pyruvate was employed as respiratory substrate, and were partially prevented by catalase, while superoxide dismutase was ineffective.
摘要
在亚铁离子存在的情况下孵育兔心脏线粒体可诱导脂质过氧化，同时伴有线粒体呼吸能力和钙离子转运能力的降低。当使用丙酮酸作为呼吸底物时，这些影响更为明显，过氧化氢酶可部分阻止这些影响，而超氧化物歧化酶则无效。
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