L-肉碱衍生物对脂质过氧化诱导的心脏线粒体损伤的影响。
Effect of L-carnitine derivatives on heart mitochondrial damage induced by lipid peroxidation.
作者信息
Ferrari R, Ciampalini G, Agnoletti G, Cargnoni A, Ceconi C, Visioli O
机构信息
University of Brescia, Cattedra di Cardiologia, Italy.
出版信息
Pharmacol Res Commun. 1988 Feb;20(2):125-32. doi: 10.1016/s0031-6989(88)80005-5.
We have incubated heart mitochondria with ferrous ions as catalyst of lipid peroxidation. Ferrous ions induced an increase of malondialdehyde formation and a reduction of mitochondrial oxygen consuming and calcium transporting capacities. L-Carnitine and Acetyl-L-Carnitine failed to prevent mitochondrial damage. Propionyl-L-Carnitine significantly improved mitochondrial function, but failed to reduce malondialdehyde formation. This protective effect was specific for Propionyl-L-Carnitine as propionic acid and L-Carnitine did not modify mitochondrial damage.
我们已将心脏线粒体与亚铁离子一起孵育，以作为脂质过氧化反应的催化剂。亚铁离子会导致丙二醛生成增加，以及线粒体耗氧能力和钙转运能力降低。左旋肉碱和乙酰左旋肉碱未能预防线粒体损伤。丙酰左旋肉碱显著改善了线粒体功能，但未能减少丙二醛的生成。这种保护作用是丙酰左旋肉碱所特有的，因为丙酸和左旋肉碱并未改变线粒体损伤情况。
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