DuBose Theodore, Nankivil Derek, LaRocca Francesco, Waterman Gar, Hagan Kristen, Polans James, Keller Brenton, Tran-Viet Du, Vajzovic Lejla, Kuo Anthony N, Toth Cynthia A, Izatt Joseph A, Farsiu Sina
Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27710, USA.
Optica. 2018 Sep 20;5(9):1027-1036. doi: 10.1364/OPTICA.5.001027. Epub 2018 Aug 23.
Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subjects. To extend the application of AOSLO to new patient populations, we have designed the first portable handheld AOSLO (HAOSLO) system. By incorporating a novel computational wavefront sensorless AO algorithm and custom optics, we have miniaturized our HAOSLO to weigh less than 200 grams. HAOSLO imaged the cones closest to the fovea with a handheld probe in adults and captured the first AO-enhanced image of cones in infants.
自适应光学扫描激光检眼镜（AOSLO）能够实现视网膜结构和功能的体内可视化，并加深对其的理解。当前一代的AOSLO占地面积大，主要限于对配合的成年受试者进行成像。为了将AOSLO的应用扩展到新的患者群体，我们设计了首个便携式手持AOSLO（HAOSLO）系统。通过纳入一种新型的无计算波前传感器自适应光学算法和定制光学元件，我们已将HAOSLO小型化，使其重量不到200克。HAOSLO使用手持探头对成人中最靠近中央凹的视锥细胞进行了成像，并获取了婴儿视锥细胞的首张自适应光学增强图像。
