School of Basic Medical Sciences, Qingdao University, No. 38 Dengzhou Road, Shibei District, Qingdao, 266000, Shandong, P. R. China.
Center for Regenerative Medicine, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, 266000, Shandong, P. R. China.
Cancer Commun (Lond). 2019 Nov 21;39(1):77. doi: 10.1186/s40880-019-0421-5.
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene, which itself belongs to an E3 ubiquitin ligase. Since the discovery of the Parkin gene in the late 1990s, researchers in many countries have begun extensive research on this gene and found that in addition to AR-JP, the Parkin gene is associated with many diseases, including type 2 diabetes, leprosy, Alzheimer's, autism, and cancer. Recent studies have found that the loss or dysfunction of Parkin has a certain relationship with tumorigenesis. In general, the Parkin gene, a well-established tumor suppressor, is deficient and mutated in a variety of malignancies. Parkin overexpression inhibits tumor cell growth and promotes apoptosis. However, the functions of Parkin in tumorigenesis and its regulatory mechanisms are still not fully understood. This article describes the structure, functions, and post-translational modifications of Parkin, and summarizes the recent advances in the tumor suppressive function of Parkin and its underlying mechanisms.
临床实践表明，帕金森蛋白（Parkin）是通过 Parkin 突变发现的常染色体隐性少年型帕金森病（AR-JP）的主要致病基因，Parkin 蛋白是 Parkin 基因的核心表达产物，Parkin 基因本身属于 E3 泛素连接酶。自 20 世纪 90 年代末发现 Parkin 基因以来，许多国家的研究人员开始对该基因进行广泛研究，发现除了 AR-JP 之外，Parkin 基因还与许多疾病有关，包括 2 型糖尿病、麻风病、阿尔茨海默病、自闭症和癌症。最近的研究发现，Parkin 的缺失或功能障碍与肿瘤发生有一定的关系。一般来说，Parkin 基因是一种成熟的肿瘤抑制基因，在多种恶性肿瘤中存在缺失和突变。Parkin 过表达抑制肿瘤细胞生长并促进细胞凋亡。然而，Parkin 在肿瘤发生中的功能及其调节机制尚不完全清楚。本文描述了 Parkin 的结构、功能和翻译后修饰，并总结了 Parkin 的肿瘤抑制功能及其潜在机制的最新进展。
