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评估印度尼西亚通过死因推断诊断缺血性心脏病的证据质量。

Evaluating the quality of evidence for diagnosing ischemic heart disease from verbal autopsy in Indonesia.

作者信息

Zhang Wenrong, Usman Yuslely, Iriawan Retno Widyastuti, Lusiana Merry, Sha Sha, Kelly Matthew, Rao Chalapati

机构信息

Department of Global Heath, Research School of Population Health, Australian National University, Canberra, ACT 2602, Australia.

National Agency for Health Research and Development, Ministry of Health, Jakarta 10110, Indonesia.

出版信息

World J Cardiol. 2019 Oct 26;11(10):244-255. doi: 10.4330/wjc.v11.i10.244.

Abstract

BACKGROUND

Mortality and cause of death data are fundamental to health policy development. Civil Registration and Vital Statistics systems are the ideal data source, but the system is still under development in Indonesia. A national Sample Registration System (SRS) has provided nationally representative mortality data from 128 sub-districts since 2014. Verbal autopsy (VA) is used in the SRS to obtain causes of death. The quality of VA data must be evaluated as part of the SRS data quality assessment.

AIM

To assess the strength of evidence used in the assignment of Ischaemic Heart Disease (IHD) as causes of death from VA.

METHODS

The sample frame for this study is the 4,070 deaths that had IHD assigned as the underlying cause in the SRS 2016 database. From these, 400 cases were randomly selected. A data extraction form and data entry template were designed to collect relevant data about IHD from VA questionnaires. A standardised categorisation was designed to assess the strength of evidence used to infer IHD as a cause of death. A pilot test of 50 cases was carried out. IBM SPSS software was used in this study.

RESULTS

Strong evidence of IHD as a cause of death was assigned based on surgery for coronary heart disease, chest pain and two out of: sudden death, history of heart disease, medical diagnosis of heart disease, or terminal shortness of breath. More than half (53%) of the questionnaires contained strong evidence. For deaths outside health facilities, VA questionnaires for male deaths contained acceptable evidence in significantly higher proportions as compared to those for female deaths. ( < 0.001). Nearly half of all IHD deaths were concentrated in the 50-69 year age group (48.40%), and a further 36.10% were aged 70 years or more. Nearly two-thirds of the deceased were male (58.40%). Smoking behaviour was found in 44.11% of IHD deaths, but this figure was 73.82% among males.

CONCLUSION

More than half of the VA questionnaires from the study sample were found to contain strong evidence to infer IHD as the cause of death. Results from medical records such as electrocardiograms, coronary angiographies, and load tests could have improved the strength of evidence and contributed to IHD cause of death diagnosis.

摘要

背景

死亡率和死因数据是卫生政策制定的基础。民事登记和人口动态统计系统是理想的数据来源,但印度尼西亚的该系统仍在发展中。自2014年以来,全国抽样登记系统(SRS)提供了来自128个分区的具有全国代表性的死亡率数据。SRS中使用口头尸检(VA)来获取死因。VA数据的质量必须作为SRS数据质量评估的一部分进行评估。

目的

评估将缺血性心脏病(IHD)认定为VA导致的死亡原因时所使用证据的力度。

方法

本研究的样本框架是2016年SRS数据库中被认定IHD为根本死因的4070例死亡病例。从中随机抽取400例。设计了数据提取表和数据录入模板,以从VA问卷中收集有关IHD的相关数据。设计了标准化分类,以评估用于推断IHD为死因的证据力度。对50例病例进行了预试验。本研究使用了IBM SPSS软件。

结果

基于冠心病手术、胸痛以及以下两项情况可认定IHD为死亡原因的有力证据:猝死、心脏病史、心脏病医学诊断或终末期呼吸急促。超过一半(53%)的问卷包含有力证据。对于医疗机构外的死亡病例,男性死亡的VA问卷中包含可接受证据的比例显著高于女性死亡的问卷(<0.001)。几乎一半的IHD死亡病例集中在50 - 69岁年龄组(48.40%),另有36.10%的患者年龄在70岁及以上。近三分之二的死者为男性(58.40%)。在44.11%的IHD死亡病例中发现有吸烟行为,但男性中的这一比例为73.82%。

结论

研究样本中超过一半的VA问卷被发现包含推断IHD为死亡原因的有力证据。心电图、冠状动脉造影和负荷试验等医疗记录的结果本可提高证据力度,并有助于IHD死因诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704a/6859301/5c2fda22d092/WJC-11-244-g001.jpg

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