Davidson Donald J, Spratt David, Liddle Alexander D
Research Department of Orthopaedics and Musculoskeletal Sciences, University College London, London, UK.
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
EFORT Open Rev. 2019 Nov 5;4(11):633-639. doi: 10.1302/2058-5241.4.180095. eCollection 2019 Nov.
Prosthetic joint infection (PJI) is associated with poor clinical outcomes and is expensive to treat.Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of the most commonly encountered complications of joint replacement and its incidence is increasing, putting a significant burden on healthcare systems.Once established, PJI is extremely difficult to eradicate as bacteria exist in biofilms which protect them from antibiotics and the host immune response.Improved understanding of the microbial pathology in PJI has generated potential new treatment strategies for prevention and eradication of biofilm associated infection including modification of implant surfaces to prevent adhesion of bacteria.Much research is currently ongoing looking at different implant surface coatings and modifications, and although most of this work has not translated into clinical medicine there has been some early clinical success. Cite this article: 2019;4:633-639. DOI: 10.1302/2058-5241.4.180095.
人工关节感染（PJI）与不良临床预后相关，且治疗费用高昂。尽管总体上并不常见（发生率在0.5%至2.2%之间），但PJI是关节置换最常遇到的并发症之一，并且其发病率正在上升，给医疗系统带来了沉重负担。一旦发生，PJI极难根除，因为细菌存在于生物膜中，生物膜可保护它们免受抗生素和宿主免疫反应的影响。对PJI中微生物病理学的深入了解产生了预防和根除生物膜相关感染的潜在新治疗策略，包括对植入物表面进行改性以防止细菌粘附。目前正在进行大量研究，探讨不同的植入物表面涂层和改性方法，尽管这项工作大多尚未转化为临床医学，但已取得了一些早期临床成功。引用本文：2019；4：633 - 639。DOI：10.1302/2058 - 5241.4.180095。
