Al-Attar Atef M, Alsalmi Fawziah A
Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 139109, Jeddah 21323, Saudi Arabia.
Saudi J Biol Sci. 2019 Nov;26(7):1865-1874. doi: 10.1016/j.sjbs.2017.02.005. Epub 2017 Feb 28.
Medicinal plants have always been an important source of new alternative effective compounds for human therapy. Currently, there are many of scientific evidences indicate that the medicinal plants contain a lot of hypoglycemic chemical compounds. The purpose of the present study was to determine the influence of olive leaves extract on hepatorenal injury in diabetic male rats. Experimental diabetes was induced by streptozotocin (STZ). The levels of serum glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen, uric acid and malondialdehyde were significantly increased, while the levels of serum superoxide dismutase, glutathione and catalase were statistically decreased in untreated diabetic rats. Moreover, the histopathological examination showed several alterations in the structure of liver and kidney in untreated diabetic rats. Treatments with low dose and high dose of olive leaves extract in diabetic rats showed remarkable reducing and protecting influences of physiological and histopathological alterations. Moreover, the highly treatment efficiency was noted in diabetic rats treated with high dose followed by low dose of olive leaves extract. Additionally, the results of this study proved that the antioxidant activities of olive leaves extract played a vital role against the hepatorenal injury induced by diabetes. Finally, this study indicates to the importance of the use of olive leaves extract as promising alternative and complementary therapeutic agent against diabetes and its complications.
药用植物一直是人类治疗新的替代有效化合物的重要来源。目前，有许多科学证据表明药用植物含有大量降血糖化合物。本研究的目的是确定橄榄叶提取物对糖尿病雄性大鼠肝肾损伤的影响。通过链脲佐菌素（STZ）诱导实验性糖尿病。在未治疗的糖尿病大鼠中，血清葡萄糖、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、γ-谷氨酰转移酶、总胆红素、肌酐、血尿素氮、尿酸和丙二醛水平显著升高，而血清超氧化物歧化酶、谷胱甘肽和过氧化氢酶水平在统计学上降低。此外，组织病理学检查显示未治疗的糖尿病大鼠肝脏和肾脏结构有多处改变。糖尿病大鼠用低剂量和高剂量橄榄叶提取物治疗显示出对生理和组织病理学改变有显著的减轻和保护作用。此外，高剂量后用低剂量橄榄叶提取物治疗的糖尿病大鼠治疗效果最佳。此外，本研究结果证明橄榄叶提取物的抗氧化活性对糖尿病诱导的肝肾损伤起着至关重要的作用。最后，本研究表明使用橄榄叶提取物作为对抗糖尿病及其并发症的有前景的替代和补充治疗剂的重要性。
