Du Zhaodong, Li Runze, Qian Xuejun, Lu Gengxi, Li Yan, He Youmin, Qu Yueqiao, Jiang Laiming, Chen Zeyu, Humayun Mark S, Chen Zhongping, Zhou Qifa
The Affiliated Hospital of Qingdao University, Department of Ophthalmology, Qingdao, China.
University of Southern California, Roski Eye Institute, Los Angeles, California, United States.
Neurophotonics. 2019 Oct;6(4):041112. doi: 10.1117/1.NPh.6.4.041112. Epub 2019 Nov 15.
The mechanosensitivity of the optic nerve head (ONH) plays a pivotal role in the pathogenesis of glaucoma. Characterizing elasticity of the ONH over changing physiological pressure may provide a better understanding of how changes in intraocular pressure (IOP) lead to changes in the mechanical environment of the ONH. Optical coherence elastography (OCE) is an emerging technique that can detect tissue biomechanics noninvasively with both high temporal and spatial resolution compared with conventional ultrasonic elastography. We describe a confocal OCE system in measuring ONH elasticity , utilizing a pressure inflation setup in which IOP is controlled precisely. We further utilize the Lamb wave model to fit the phase dispersion curve during data postprocessing. We present a reconstruction of Young's modulus of the ONH by combining our OCE system with a Lamb wave model for the first time. This approach enables the quantification of Young's modulus of the ONH, which can be fit using a piecewise polynomial to the corresponding IOP.
视神经乳头（ONH）的机械敏感性在青光眼发病机制中起关键作用。表征在生理压力变化时ONH的弹性，可能有助于更好地理解眼内压（IOP）的变化如何导致ONH机械环境的改变。光学相干弹性成像（OCE）是一种新兴技术，与传统超声弹性成像相比，它能够以高时间和空间分辨率无创检测组织生物力学。我们描述了一种用于测量ONH弹性的共焦OCE系统，该系统利用了一种精确控制IOP的压力充气装置。在数据后处理过程中，我们进一步利用兰姆波模型来拟合相位色散曲线。我们首次将OCE系统与兰姆波模型相结合，实现了ONH杨氏模量的重建。这种方法能够量化ONH的杨氏模量，该模量可以用分段多项式拟合到相应的IOP。
