Biomedical Science, University of Applied Sciences Wiener Neustadt, Johannes-Gutenberg-Straße 3, 2700, Wiener Neustadt, Austria.
Gepflegt Wohnen GmbH, Nierathberg 182, 8412, Allerheiligen bei Wildon, Austria.
Wien Klin Wochenschr. 2020 Jan;132(1-2):42-46. doi: 10.1007/s00508-019-01588-7. Epub 2019 Dec 12.
Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60-96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer's disease).
先前的研究已经强调，亚精胺具有通过自噬触发溶解淀粉样β斑块的重要过程的能力。本文主要关注血清中亚精胺水平与年龄和简易精神状态检查表现之间的相关性。这将作为正在进行的多中心安慰剂对照研究的前提，该研究侧重于口服亚精胺补充对记忆表现的影响。在施蒂利亚的 6 家养老院中，对 80 名年龄在 60-96 岁的受试者进行了记忆测试，并采集了血液样本以确定亚精胺浓度。结果显示，亚精胺浓度与简易精神状态检查评分之间存在显著相关性（p=0.025）。基于所证明的依赖性，可以得出结论，亚精胺可能适合作为神经认知变化（老年痴呆症或阿尔茨海默病）诊断的生物标志物。
