• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

补充 1 年后，衰老的痴呆症患者补充亚精胺后产生积极效果。

The positive effect of spermidine in older adults suffering from dementia after 1 year.

机构信息

Biomedical Science, University of Applied Sciences Wiener Neustadt, Johannes-Gutenberg-Str. 3, 2700, Wiener Neustadt, Austria.

Gepflegt Wohnen Hart bei Graz GmbH, Pachern Hauptstr. 152d, 8075, Hart bei Graz, Austria.

出版信息

Wien Klin Wochenschr. 2024 Jan;136(1-2):64-66. doi: 10.1007/s00508-023-02226-z. Epub 2023 Jun 7.

DOI:10.1007/s00508-023-02226-z
PMID:37284840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10776733/
Abstract

BACKGROUND

A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could be observed an improvement in memory performance after one year.

METHOD

45 residents of the nursing home "Gepflegt Wohnen" in Hart bei Graz, Styria, Austria, were given a daily dose of 3.3 mg spermidine in their diet for one year.

RESULTS

The comparison of the MMSE test results at baseline and after one year demonstrated a significant (p < 0.001) difference. The mean improvement is 5 points.

CONCLUSION

The new results confirm the already proven positive effect of oral spermidine intake on memory performance.

摘要

背景

已经证明，口服亚精胺 3 个月对记忆表现有积极影响。本研究的延续旨在检验一年后记忆表现是否有所改善。

方法

奥地利施蒂利亚州格拉茨哈特市养老院“Gepflegt Wohnen”的 45 名居民每天在饮食中摄入 3.3 毫克亚精胺，持续一年。

结果

将基线时和一年后的 MMSE 测试结果进行比较，结果显示差异具有统计学意义（p<0.001）。平均改善为 5 分。

结论

新结果证实了口服亚精胺摄入对记忆表现的积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c36/10776733/c516bf90781c/508_2023_2226_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c36/10776733/c516bf90781c/508_2023_2226_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c36/10776733/c516bf90781c/508_2023_2226_Fig1_HTML.jpg

相似文献

1
The positive effect of spermidine in older adults suffering from dementia after 1 year.补充 1 年后，衰老的痴呆症患者补充亚精胺后产生积极效果。
Wien Klin Wochenschr. 2024 Jan;136(1-2):64-66. doi: 10.1007/s00508-023-02226-z. Epub 2023 Jun 7.
2
The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial.亚精胺可改善老年痴呆症患者的认知功能：为期 3 个月的临床试验的初步结果。
Wien Klin Wochenschr. 2021 May;133(9-10):484-491. doi: 10.1007/s00508-020-01758-y. Epub 2020 Nov 19.
3
Spermidine in dementia : Relation to age and memory performance.精胺与痴呆症：与年龄和记忆表现的关系。
Wien Klin Wochenschr. 2020 Jan;132(1-2):42-46. doi: 10.1007/s00508-019-01588-7. Epub 2019 Dec 12.
4
Prevalence of psychotropic medication use among German and Austrian nursing home residents: a comparison of 3 cohorts.德国和奥地利养老院居民精神药物使用的流行率：3 个队列的比较。
J Am Med Dir Assoc. 2012 Feb;13(2):187.e7-187.e13. doi: 10.1016/j.jamda.2011.03.007. Epub 2011 May 6.
5
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.亚精胺对痴呆风险老年人记忆表现的影响：一项随机对照试验。
Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4.
6
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.补充亚精胺对主观认知下降老年人认知和生物标志物的影响（SmartAge）-一项随机对照试验的研究方案。
Alzheimers Res Ther. 2019 May 1;11(1):36. doi: 10.1186/s13195-019-0484-1.
7
DEMDATA: The Austrian-Czech institutional long term care project - design and protocol of a two-centre cross sectional study.DEMDATA：奥地利-捷克机构长期护理项目——一项两中心横断面研究的设计与方案
BMC Health Serv Res. 2017 Apr 20;17(1):296. doi: 10.1186/s12913-017-2244-x.
8
The best evidence for minimizing resistance-to-care during assisted personal care for older adults with dementia in nursing homes: a systematic review.养老院中为患有痴呆症的老年人提供协助性个人护理时将护理阻力降至最低的最佳证据：一项系统综述。
JBI Libr Syst Rev. 2012;10(58):4622-4632. doi: 10.11124/jbisrir-2012-431.
9
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.亚精胺的摄入量与老年人的大脑皮质厚度和海马体体积有关。
Neuroimage. 2020 Nov 1;221:117132. doi: 10.1016/j.neuroimage.2020.117132. Epub 2020 Jul 3.
10
Cross-sectional study of prevalence of dementia, behavioural symptoms, mobility, pain and other health parameters in nursing homes in Austria and the Czech Republic: results from the DEMDATA project.奥地利和捷克共和国养老院痴呆、行为症状、活动能力、疼痛和其他健康参数的横断面研究：来自 DEMDATA 项目的结果。
BMC Geriatr. 2018 Aug 13;18(1):178. doi: 10.1186/s12877-018-0870-8.

引用本文的文献

1
Non-Linear Association of Dietary Polyamines with the Risk of Incident Dementia: Results from Population-Based Cohort of the UK Biobank.饮食多胺与新发痴呆风险的非线性关联：来自英国生物银行基于人群的队列研究结果。
Nutrients. 2024 Aug 20;16(16):2774. doi: 10.3390/nu16162774.
2
Postbiotics as Molecules Targeting Cellular Events of Aging Brain-The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases.后生元作为靶向衰老大脑细胞事件的分子-在神经退行性疾病的发病机制、预防和治疗中的作用。
Nutrients. 2024 Jul 12;16(14):2244. doi: 10.3390/nu16142244.
3
Polyamine Dysregulation and Nucleolar Disruption in Alzheimer's Disease.

本文引用的文献

1
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.补充亚精胺对主观认知下降的老年人认知和生物标志物的影响：一项随机临床试验。
JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875.
2
The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial.亚精胺可改善老年痴呆症患者的认知功能：为期 3 个月的临床试验的初步结果。
Wien Klin Wochenschr. 2021 May;133(9-10):484-491. doi: 10.1007/s00508-020-01758-y. Epub 2020 Nov 19.
3
Statistically significant but clinically irrelevant correlation?
多胺失调与阿尔茨海默病中的核仁破坏。
J Alzheimers Dis. 2024;98(3):837-857. doi: 10.3233/JAD-231184.
4
Research Progress of Mitophagy in Alzheimer's Disease.阿尔茨海默病中细胞自噬的研究进展
Curr Alzheimer Res. 2024;20(12):827-844. doi: 10.2174/0115672050300063240305074310.
具有统计学显著性但临床无相关性的关联？
Wien Klin Wochenschr. 2020 Sep;132(17-18):547-548. doi: 10.1007/s00508-020-01634-9. Epub 2020 Mar 18.
4
Spermidine in dementia : Relation to age and memory performance.精胺与痴呆症：与年龄和记忆表现的关系。
Wien Klin Wochenschr. 2020 Jan;132(1-2):42-46. doi: 10.1007/s00508-019-01588-7. Epub 2019 Dec 12.