Badulla Wafa F S, Ben Yahiya Abdul-Rahman
Department of Analytical Chemistry, Faculty of Pharmacy, Aden University, Aden, Yemen.
Addict Health. 2019 Jul;11(3):148-155. doi: 10.22122/ahj.v11i3.237.
Saliva is a biological fluid that has multiple protective functions. These functions can be attained only if the saliva keeps certain physo-chemical properties such as pH. The main purpose of the current study was to compare the salivary pH among khat chewers and non-khat chewers before and after specific intervals (15, 30, and 60 minutes) of using three commercially available mouthwashes (MWs).
In this cross sectional study, thirty pharmacy student volunteers were divided into three groups of 10 for the three MWs. Each group was then subdivided into 5 volunteers as khat chewer and non-khat chewer. The statistical evaluation was carried out by using paired t-test and analysis of variance (ANOVA) for in vivo study of salivary pH.
Low salivary pH in all khat-user volunteers before and after using MWs was indicated. There was an increase in the salivary pH after 15 minutes of rinsing with the three selected MWs for both groups of volunteers, after that there was a gradual decrease to the initial pH. The difference between the three groups was not significant at baseline and after 15 minutes, but there was a significant difference after 30 and 60 minutes for the non-khat-chewing and khat-chewing volunteers.
It can be concluded that using MWs results in altering salivary pH and continuous khat chewing lowers the baseline pH of saliva and ability to compensate the change of salivary pH.
唾液是一种具有多种保护功能的生物流体。只有当唾液保持某些物理化学性质（如pH值）时，这些功能才能实现。本研究的主要目的是比较咀嚼恰特草者和不咀嚼恰特草者在使用三种市售漱口水（MWs）特定时间段（15、30和60分钟）前后的唾液pH值。
在这项横断面研究中，30名药学专业学生志愿者被分为三组，每组10人，分别使用三种漱口水。然后每组再细分为5名咀嚼恰特草者和5名不咀嚼恰特草者。采用配对t检验和方差分析（ANOVA）对唾液pH值进行体内研究的统计评估。
结果表明，所有咀嚼恰特草者在使用漱口水前后唾液pH值均较低。两组志愿者在使用三种选定的漱口水漱口15分钟后，唾液pH值均有所升高，之后逐渐降至初始pH值。三组在基线时和15分钟后差异不显著，但在30分钟和60分钟后，不咀嚼恰特草者和咀嚼恰特草者之间存在显著差异。
可以得出结论，使用漱口水会改变唾液pH值，持续咀嚼恰特草会降低唾液的基线pH值以及补偿唾液pH值变化的能力。
