Eye Hospital, China Academy Of Chinese Medical Sciences, Beijing, China.
Department Of Ocular Microbiology, Beijing Institute Of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
BMC Ophthalmol. 2019 Dec 19;19(1):262. doi: 10.1186/s12886-019-1266-z.
Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide more detailed analysis of 272 cases of EKC in 8 years, describe the differences of the clinical features among different age groups, and establish new clinical grading criteria.
272 individuals were reviewed (2011-2019) in Beijing China. All the patients were classified into 3 grades according to the new grading criteria. The typical clinical signs of EKC and the photographs of the multiple subepithelial corneal infiltrates (MSI) were collected and analyzed. The number of 3 grades among and within different age groups were compared. The incidence of the typical signs among and within different age groups were compared. The proportion of each region of the cornea involved by MSI were compared.
No significant differences were detected among the 4 groups in terms of the number of mild, moderate and severe cases, no matter in all-patients analysis (P = 0.271) nor in acute-phase-patients analysis (P = 0.203). The proportion of the severe cases was the highest among all patients (P = 0.000). Among the incidence of the typical signs, corneal involvement was the most common accounting for 69.8% (P<0.05). The probability of central region involvement was significantly higher than that of pericentral region involvement (P = 0.015) and peripheral region involvement (P = 0.000).
Appropriate attention should be paid on EKC, because of the considerable proportion of severe cases, the high incidence of corneal lesion, and the high incidence of central region involvement of MSI.
流行性角膜结膜炎（EKC）是全球最常见的眼部感染之一。对不同年龄组临床表现的分析有助于更好地了解该疾病。本研究旨在对 8 年来 272 例 EKC 患者进行更详细的分析，描述不同年龄组之间临床特征的差异，并建立新的临床分级标准。
回顾 2011-2019 年在中国北京的 272 例患者。所有患者根据新的分级标准分为 3 级。收集并分析 EKC 的典型临床特征和多发性上皮下角膜浸润（MSI）的照片。比较不同年龄组之间和内部的 3 级患者数量。比较不同年龄组之间和内部的典型体征的发生率。比较 MSI 累及角膜各区域的比例。
在所有患者的分析中（P=0.271）和急性患者的分析中（P=0.203），无论在轻度、中度和重度病例的数量方面，4 组之间均无显著差异。在所有患者中，严重病例的比例最高（P=0.000）。在典型体征的发生率方面，角膜受累最为常见，占 69.8%（P<0.05）。中央区域受累的概率明显高于周边区域受累（P=0.015）和周边区域受累（P=0.000）。
应适当关注 EKC，因为严重病例的比例相当大，角膜病变的发病率高，MSI 的中央区域受累发生率高。
