Laboratório de Anelasticidade e Biomateriais, UNESP - Univ Estadual Paulista, Bauru, SP, Brazil.
IBTN-Br - Institute of Biomaterials, Tribocorrosion and Nanomedicine - Brazilian Branch, Bauru, SP, Brazil.
Artif Organs. 2020 Aug;44(8):811-817. doi: 10.1111/aor.13624. Epub 2020 Jan 31.
Titanium alloys are widely used in the biomedical field due to their excellent resistance to corrosion, high mechanical strength/density ratio, low elastic modulus, and good biocompatibility. Niobium is a β-stabilizer element that has the potential to decrease elastic modulus and possesses excellent corrosion resistance. In this article, Ti-15Nb alloy was prepared via arc-melting, with the aim of using it in biomedical applications to replace implants that fail due to mechanical incompatibility with human bone. This Ti-15Nb alloy was structurally, chemically, and microstructurally characterized. Its mechanical properties were analyzed via Vickers microhardness and elastic modulus measurements. The cytotoxicity of the alloy was evaluated via direct and indirect MTT tests. In the direct MTT test, the cells were grown on alloy and in the indirect test, Ti-15Nb alloy extracts were prepared (1 g/1 mL at 310 K for 48 hours). The results of chemical composition showed that the alloy produced has good quality and low content of gaseous impurities, such as oxygen and nitrogen. The obtained results for structure and microstructure indicated the presence of the martensite α' phase. The microhardness of the Ti-15Nb alloy is superior to that of cp-Ti due to solid solution hardening, and the alloy has a better elastic modulus as compared to pure titanium. Cytotoxic effects were not observed. The Ti-15Nb alloy shows good results of mechanical properties and does not show cytotoxic effects. In addition, morphological variations were not found in the cells and good cell adhesion in all the studied conditions was observed. In general, the alloy proposed in this article has satisfactory characteristics as a biomedical material.
钛合金由于其优异的耐腐蚀性、高机械强度/密度比、低弹性模量和良好的生物相容性而被广泛应用于生物医学领域。铌是一种β稳定元素，具有降低弹性模量的潜力，并且具有优异的耐腐蚀性。在本文中，通过电弧熔炼制备了 Ti-15Nb 合金，旨在将其用于生物医学应用中，以替代因与人体骨骼机械不兼容而失效的植入物。对 Ti-15Nb 合金进行了结构、化学和微观结构表征。通过维氏硬度和弹性模量测量分析了其力学性能。通过直接和间接 MTT 试验评估了合金的细胞毒性。在直接 MTT 试验中，细胞在合金上生长，在间接试验中，制备了 Ti-15Nb 合金提取物（310 K 下 1 g/1 mL，48 小时）。化学成分的结果表明，所生产的合金质量良好，气体杂质（如氧和氮）含量低。所获得的结构和微观结构结果表明存在马氏体α'相。由于固溶强化，Ti-15Nb 合金的硬度优于 cp-Ti，并且与纯钛相比，其弹性模量更好。没有观察到细胞毒性作用。Ti-15Nb 合金具有良好的力学性能且没有细胞毒性作用。此外，在所有研究条件下都未发现细胞形态发生变化，并且观察到所有条件下细胞均良好附着。总的来说，本文提出的合金作为生物医学材料具有令人满意的特性。
