National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
ICAR-National Institute of Biotic Stress Management, Baronda, India.
Transbound Emerg Dis. 2020 May;67(3):1062-1067. doi: 10.1111/tbed.13463. Epub 2020 Jan 7.
Porcine circovirus type 3 (PCV3), a novel circovirus, has been reported recently from major swine growing countries globally, and the virus is associated with diseases like porcine dermatitis, nephropathy syndrome and reproductive failure. This report describes the identification of PCV3 associated with reproductive failure in sows and piglet mortality and circulation of the virus in healthy pigs in India. The pathological changes in various tissues from stillborn piglet and characterization of the virus genomes were reported. The genome sequences of Indian PCV3 strains showed 91.4%-99.8% nucleotide identity with other sequences of PCV3 strains circulating worldwide. The phylogenetic analysis showed clustering of Indian strains into a separate group with the isolate from USA (MN/2016) under PCV3a genotype. The results confirmed the circulation of PCV3 in Indian pigs and its association with clinical cases. This study speculates emergence of PCV3 as an important pig pathogen in the country, which warrants the thorough investigation on PCV3 epidemiology, pathogenesis and to implement the control measures.
猪圆环病毒 3 型（PCV3）是一种新发现的圆环病毒，目前已在全球主要养猪国家报道，该病毒与猪皮炎肾病综合征和繁殖障碍等疾病有关。本研究报告了在印度，PCV3 与母猪繁殖障碍和仔猪死亡以及健康猪群中病毒的流行有关。报道了死胎仔猪各组织的病理变化和病毒基因组的特征。印度 PCV3 毒株的基因组序列与世界其他地区流行的 PCV3 毒株的核苷酸同源性为 91.4%-99.8%。系统进化分析显示，印度分离株与美国（MN/2016）分离株一起，在 PCV3a 基因型下聚类为一个单独的组。研究结果证实了 PCV3 在印度猪群中的流行及其与临床病例的关系。本研究推测 PCV3 已成为该国的一种重要猪病病原体，因此有必要对其进行 PCV3 流行病学、发病机制的深入调查，并实施控制措施。
