Keilani Chafik, Augstburger Edouard, Robin Mathieu, Beaugrand Amélie, Ores Raphaëlle, Sahel José-Alain, Ayello-Scheer Sarah
Quinze-Vingts National Hospital, Department of Ophthalmology IV / Sorbonne University, Faculty of Medicine Pierre-et-Marie-Curie/Assistance Publique-Hopitaux de Paris, Paris, France
Quinze-Vingts National Hospital, Department of Ophthalmology III, Paris, France
Turk J Ophthalmol. 2019 Dec 31;49(6):334-341. doi: 10.4274/tjo.galenos.2019.24294.
To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane HD) and silicone oil-Densiron-68 (Densiron 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR).
This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane HD or Densiron 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications.
Twenty-three eyes were included: 16 eyes with Densiron 68 tamponade and 7 eyes with Oxane HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron 68 group (100%) than in the Oxane HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane HD, but in none of the patients under Densiron 68 (p=0.001). Six months after surgery, mean BVCA values (+/- standard deviation) with Densiron 68 and Oxane HD were 0.83±0.62 logMAR and 1.81±0.65 logMAR, respectively. BVCA was significantly better in the Densiron 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation.
Densiron 68 appears to be more effective than Oxane HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference.
比较两种高密度硅油（HDSO），即硅油-RMN3（Oxane HD）和硅油-Densiron-68（Densiron 68），用于治疗与下方增殖性玻璃体视网膜病变（PVR）相关的复杂性视网膜脱离（RD）的生化结果、有效性和耐受性。
这是一项回顾性、单中心、比较性病例系列研究，纳入了2014年9月至2016年6月期间接受治疗的23例患者。主要纳入标准为在玻璃体切除术后接受Oxane HD或Densiron 68治疗的伴有下方PVR的RD。主要观察指标为6个月时的解剖学成功、RD复发率和最佳矫正视力（BCVA）。次要观察指标为短期并发症。
共纳入23只眼：16只眼采用Densiron 68填塞，7只眼采用Oxane HD填塞。Densiron 68组HDSO下的解剖学成功率（100%）显著高于Oxane HD组（42.8%）（p = 0.0455）。Oxane HD治疗的眼中有42.8%观察到RD复发，但Densiron 68治疗的患者中无一例复发（p = 0.001）。术后6个月，Densiron 68和Oxane HD的平均BCVA值（±标准差）分别为0.83±0.62 logMAR和1.81±0.65 logMAR。Densiron 68组的BCVA明显更好（p = 0.006）。在眼压、乳化或眼内炎症方面未观察到显著差异。
Densiron 68在治疗与PVR相关的RD方面似乎比Oxane HD更有效。需要进行一项随机、对照、干预性研究来证实这种差异。
