University of Cologne, Center of Ophthalmology, Department of Vitreo-Retinal Surgery, Kerpener Str. 62, Cologne 50924, Germany.
Br J Ophthalmol. 2010 Apr;94(4):509-12. doi: 10.1136/bjo.2009.170852. Epub 2009 Dec 2.
To investigate whether the emulsification of conventional silicone oils can be reduced by adding small amounts of silicone molecules of a very long chain length.
Siluron 1000, Siluron 2000, Siluron 5000, Acri.Sil-Ol 5000, Oxane 5700, Densiron 68 LV, Densiron 68 and Densiron 68 HV (0.5 ml) were each tested along with either plasma or serum (0.5 ml) in a glass cuvette. Emulsification was induced by sonication and documented by photography. The total area of emulsified oil was assessed using the ImageJ software.
The addition of small amounts of very-long-chain silicone molecules significantly reduced the emulsification for 1000 cSt silicone oil (Siluron 2000) and for 1000 cSt silicone oil with an admixture of F6H8 (Densiron 68 HV).
New low-viscosity silicone oils show a reduced emulsification similar to that of 5000 cSt oils. In future, it may be possible to avoid using 5000 cSt oils. The findings may foster silicone oil surgery in general, and in particular the application of small-incision techniques.
研究通过添加少量非常长链长的硅分子是否可以减少常规硅油的乳化。
将 Siluron 1000、Siluron 2000、Siluron 5000、Acri.Sil-Ol 5000、Oxane 5700、Densiron 68 LV、Densiron 68 和 Densiron 68 HV（0.5ml）分别与血浆或血清（0.5ml）一起在玻璃试管中进行测试。通过超声处理诱导乳化，并通过摄影记录。使用 ImageJ 软件评估乳化油的总面积。
少量非常长链硅分子的添加显著降低了 1000cSt 硅油（Siluron 2000）和含有 F6H8 混合物的 1000cSt 硅油（Densiron 68 HV）的乳化。
新型低粘度硅油的乳化程度类似于 5000cSt 油。将来，可能可以避免使用 5000cSt 油。这些发现可能会促进硅油手术的发展，特别是微创手术技术的应用。
